Cyclic peptide oral bioavailability: lessons from the past

Wang, Conan K. and Craik, David J. (2016) Cyclic peptide oral bioavailability: lessons from the past. Biopolymers, 106 6: 901-909. doi:10.1002/bip.22878

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Author Wang, Conan K.
Craik, David J.
Title Cyclic peptide oral bioavailability: lessons from the past
Journal name Biopolymers   Check publisher's open access policy
ISSN 1097-0282
0006-3525
Publication date 2016-11-01
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1002/bip.22878
Open Access Status File (Author Post-print)
Volume 106
Issue 6
Start page 901
End page 909
Total pages 9
Place of publication Hoboken, NJ, United States
Publisher John Wiley & Sons
Language eng
Abstract Achieving high oral bioavailability for drugs is a key design objective in drug development. It is not surprising then that with the growing expectation of peptides as future drugs, there has also been an increasing interest in developing oral peptide therapeutics. Brought to the fore are questions such as what makes peptides orally bioavailable and how this can be achieved; questions which have inspired research into the area for decades. Early research in the area focused on linear peptides with more recent literature focusing on cyclic peptides, motivated in part by cyclic peptides like cyclosporine A that have demonstrated drug-like oral bioavailability. In this review, we take a look at research on the oral bioavailability of peptides, focusing on factors that affect passive permeability.
Keyword Oral absorption
Permeability
Cyclic peptide
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: HERDC Pre-Audit
Institute for Molecular Bioscience - Publications
 
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Created: Thu, 01 Dec 2016, 00:31:37 EST by Susan Allen on behalf of Institute for Molecular Bioscience