Discovery, isolation and structural characterization of cyclotides from Viola sumatrana miq

Niyomploy, Ploypat, Chan, Lai Yue, Poth, Aaron G., Colgrave, Michelle L. and Sangvanich, Polkit (2016) Discovery, isolation and structural characterization of cyclotides from Viola sumatrana miq. Biopolymers, 106 6: 796-805. doi:10.1002/bip.22914

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Author Niyomploy, Ploypat
Chan, Lai Yue
Poth, Aaron G.
Colgrave, Michelle L.
Sangvanich, Polkit
Title Discovery, isolation and structural characterization of cyclotides from Viola sumatrana miq
Formatted title
Discovery, isolation and structural characterization of cyclotides from Viola sumatrana miq
Journal name Biopolymers   Check publisher's open access policy
ISSN 1097-0282
0006-3525
Publication date 2016-11-01
Sub-type Article (original research)
DOI 10.1002/bip.22914
Open Access Status File (Author Post-print)
Volume 106
Issue 6
Start page 796
End page 805
Total pages 10
Place of publication Hoboken, NJ, United States
Publisher John Wiley & Sons
Collection year 2017
Language eng
Formatted abstract
Cyclotides are cyclic peptides from plants in the Violaceae, Rubiaceae, Fabaceae, Cucurbitaceae, and Solanaceae families. They are sparsely distributed in most of these families, but appear to be ubiquitous in the Violaceae, having been found in every plant so far screened from this family. However, not all geographic regions have been examined and here we report the discovery of cyclotides from a Viola species from South-East Asia. Two novel cyclotides (Visu 1 and Visu 2) and two known cyclotides (kalata S and kalata B1) were identified in V. sumatrana. NMR studies revealed that kalata S and kalata B1 had similar secondary structures. Their biological activities were determined in cytotoxicity assays; both had similar cytotoxic activity and were more toxic to U87 cells compared with other cell lines. Overall, the study strongly supports the ubiquity of cyclotides in the Violaceae and adds to our understanding of their distribution and cytotoxic activity.
Keyword Cyclic peptides
Cyclotides
Kalata B1
Natural products
Viola plants
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: HERDC Pre-Audit
Institute for Molecular Bioscience - Publications
 
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Created: Thu, 01 Dec 2016, 00:23:08 EST by Susan Allen on behalf of Institute for Molecular Bioscience