Worldwide Esophageal Cancer Collaboration: pathologic staging data

Rice, T. W., Chen, L. -Q., Hofstetter, W. L., Smithers, B. M., Rusch, V. W., Wijnhoven, B. P. L., Chen, K. L., Davies, A. R., D'Journo, X. B., Kesler, K. A., Luketich, J. D., Ferguson, M. K., Raesaenen, J. V., van Hillegersberg, R., Fang, W., Durand, L., Cecconello, I., Allum, W. H., Cerfolio, R. J., Pera, M., Griffin, S. M., Burger, R., Liu, J. -F., Allen, M. S., Law, S., Watson, T. J., Darling, G. E., Scott, W. J., Duranceau, A., Denlinger, C. E., Schipper, P. H., Lerut, T. E. M. R., Orringer, M. B., Ishwaran, H., Apperson-Hansen, C., DiPaola, L. M., Semple, M. E. and Blackstone, E. H. (2016) Worldwide Esophageal Cancer Collaboration: pathologic staging data. Diseases of the Esophagus, 29 7: 724-733. doi:10.1111/dote.12520


Author Rice, T. W.
Chen, L. -Q.
Hofstetter, W. L.
Smithers, B. M.
Rusch, V. W.
Wijnhoven, B. P. L.
Chen, K. L.
Davies, A. R.
D'Journo, X. B.
Kesler, K. A.
Luketich, J. D.
Ferguson, M. K.
Raesaenen, J. V.
van Hillegersberg, R.
Fang, W.
Durand, L.
Cecconello, I.
Allum, W. H.
Cerfolio, R. J.
Pera, M.
Griffin, S. M.
Burger, R.
Liu, J. -F.
Allen, M. S.
Law, S.
Watson, T. J.
Darling, G. E.
Scott, W. J.
Duranceau, A.
Denlinger, C. E.
Schipper, P. H.
Lerut, T. E. M. R.
Orringer, M. B.
Ishwaran, H.
Apperson-Hansen, C.
DiPaola, L. M.
Semple, M. E.
Blackstone, E. H.
Title Worldwide Esophageal Cancer Collaboration: pathologic staging data
Journal name Diseases of the Esophagus   Check publisher's open access policy
ISSN 1442-2050
1120-8694
Publication date 2016-10-01
Year available 2016
Sub-type Article (original research)
DOI 10.1111/dote.12520
Open Access Status Not yet assessed
Volume 29
Issue 7
Start page 724
End page 733
Total pages 10
Place of publication Cary, NC, United States
Publisher John Wiley & Sons
Language eng
Subject 2715 Gastroenterology
Abstract We report data—simple descriptions of patient characteristics, cancer categories, and non–risk-adjusted survival—for patients with pathologically staged cancer of the esophagus and esophagogastric junction after resection or ablation with no preoperative therapy from the Worldwide Esophageal Cancer Collaboration (WECC). Thirty-three institutions from six continents submitted de-identified data using standard definitions: demographics, comorbidities, clinical cancer categories, and all-cause mortality from first management decision. Of 13,300 patients, 5,631 had squamous cell carcinoma, 7,558 adenocarcinoma, 85 adenosquamous carcinoma, and 26 undifferentiated carcinoma. Patients were older (62 years) men (80%) with normal body mass index (51%), little weight loss (1.8 kg), 0–2 ECOG performance status (83%), and a history of smoking (70%). Cancers were pT1 (24%), pT2 (15%), pT3 (50%), pN0 (52%), pM0 (93%), and pG2-G3 (78%); most involved distal esophagus (71%). Non–risk-adjusted survival for both squamous cell carcinoma and adenocarcinoma was monotonic and distinctive across pTNM. Survival was more distinctive for adenocarcinoma than squamous cell carcinoma when pT was ordered by pN. Survival for pTis-1 adenocarcinoma was better than for squamous cell carcinoma, although monotonic and distinctive for both. WECC pathologic staging data is improved over that of the 7th edition, with more patients studied and patient and cancer variables collected. These data will be the basis for the 8th edition cancer staging manuals following risk adjustment for patient, cancer, and treatment characteristics, and should direct 9th edition data collection. However, the role of pure pathologic staging as the principal point of reference for esophageal cancer staging is waning.
Keyword Cancer staging
Decision-making
Esophagectomy
Prognostication
Survival
Q-Index Code C1
Q-Index Status Provisional Code
Grant ID R01 CA163739
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
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