The current state of peritoneal dialysis

Mehrotra, Rajnish, Devuyst, Olivier, Davies, Simon J. and Johnson, David W. (2016) The current state of peritoneal dialysis. Journal of the American Society of Nephrology, 27 11: 3238-3252. doi:10.1681/ASN.2016010112

Author Mehrotra, Rajnish
Devuyst, Olivier
Davies, Simon J.
Johnson, David W.
Title The current state of peritoneal dialysis
Journal name Journal of the American Society of Nephrology   Check publisher's open access policy
ISSN 1046-6673
Publication date 2016-11-01
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1681/ASN.2016010112
Open Access Status PMC
Volume 27
Issue 11
Start page 3238
End page 3252
Total pages 15
Place of publication Washington, DC, United States
Publisher American Society of Nephrology
Language eng
Subject 2727 Nephrology
Abstract Technical innovations in peritoneal dialysis (PD), now used widely for the long-term treatment of ESRD, have significantly reduced therapy-related complications, allowing patients to be maintained on PD for longer periods. Indeed, the survival rate for patients treated with PD is now equivalent to that with in-center hemodialysis. In parallel, changes in public policy have spurred an unprecedented expansion in the use of PD in many parts of the world. Meanwhile, our improved understanding of the molecular mechanisms involved in solute and water transport across the peritoneum and of the pathobiology of structural and functional changes in the peritoneum with long-term PD has provided new targets for improving efficiency and for intervention. As with hemodialysis, almost half of all deaths on PD occur because of cardiovascular events, and there is great interest in identifying modality-specific factors contributing to these events. Notably, tremendous progress has been made in developing interventions that substantially reduce the risk of PD-related peritonitis. Yet the gains have been unequal among individual centers, primarily because of unequal clinical application of knowledge gained from research. The work to date has further highlighted the areas in need of innovation as we continue to strive to improve the health and outcomes of patients treated with PD.
Keyword Peritoneal membrane
Peritoneal dialysis
End-stage renal disease
Cardiovascular disease
Life-threatening dialysis complications
Q-Index Code C1
Q-Index Status Provisional Code
Grant ID R01 DK099165
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
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