Epimutational profile of hematologic malignancies as attractive target for new epigenetic therapies

Fratta, Elisabetta, Montico, Barbara, Rizzo, Aurora, Colizzi, Francesca, Sigalotti, Luca and Dolcetti, Riccardo (2016) Epimutational profile of hematologic malignancies as attractive target for new epigenetic therapies. Oncotarget, 7 35: 57327-57350. doi:10.18632/oncotarget.10033


Author Fratta, Elisabetta
Montico, Barbara
Rizzo, Aurora
Colizzi, Francesca
Sigalotti, Luca
Dolcetti, Riccardo
Title Epimutational profile of hematologic malignancies as attractive target for new epigenetic therapies
Journal name Oncotarget   Check publisher's open access policy
ISSN 1949-2553
Publication date 2016-06-14
Sub-type Article (original research)
DOI 10.18632/oncotarget.10033
Open Access Status DOI
Volume 7
Issue 35
Start page 57327
End page 57350
Total pages 24
Place of publication Albany, NY, United States
Publisher Impact Journals LLC
Language eng
Subject 2730 Oncology
Abstract In recent years, recurrent somatic mutations in epigenetic regulators have been identified in patients with hematological malignancies. Furthermore, chromosomal translocations in which the fusion protein partners are themselves epigenetic regulators or where epigenetic regulators are recruited/targeted by oncogenic fusion proteins have also been described. Evidence has accumulated showing that "epigenetic drugs" are likely to provide clinical benefits in several hematological malignancies, granting their approval for the treatment of myelodysplastic syndromes and cutaneous T-cell lymphomas. A large number of pre-clinical and clinical trials evaluating epigenetic drugs alone or in combination therapies are ongoing. The aim of this review is to provide a comprehensive summary of known epigenetic alterations and of the current use of epigenetic drugs for the treatment of hematological malignancies.
Keyword 5-aza-2'-deoxycytidine
Azacytidine
DNA methylation
Hematological malignancies
Histone modifications
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: HERDC Pre-Audit
UQ Diamantina Institute Publications
 
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