The many faces of elongator in neurodevelopment and disease

Kojic, Marija and Wainwright, Brandon (2016) The many faces of elongator in neurodevelopment and disease. Frontiers in Molecular Neuroscience, 9 NOV2016: . doi:10.3389/fnmol.2016.00115


Author Kojic, Marija
Wainwright, Brandon
Title The many faces of elongator in neurodevelopment and disease
Journal name Frontiers in Molecular Neuroscience   Check publisher's open access policy
ISSN 1662-5099
Publication date 2016-11-01
Year available 2016
Sub-type Critical review of research, literature review, critical commentary
DOI 10.3389/fnmol.2016.00115
Open Access Status DOI
Volume 9
Issue NOV2016
Total pages 10
Place of publication Lausanne, Switzerland
Publisher Frontiers Research Foundation
Language eng
Abstract Development of the nervous system requires a variety of cellular activities, such as proliferation, migration, axonal outgrowth and guidance and synapse formation during the differentiation of neural precursors into mature neurons. Malfunction of these highly regulated and coordinated events results in various neurological diseases. The Elongator complex is a multi-subunit complex highly conserved in eukaryotes whose function has been implicated in the majority of cellular activities underlying neurodevelopment. These activities include cell motility, actin cytoskeleton organization, exocytosis, polarized secretion, intracellular trafficking and the maintenance of neural function. Several studies have associated mutations in Elongator subunits with the neurological disorders familial dysautonomia (FD), intellectual disability (ID), amyotrophic lateral sclerosis (ALS) and rolandic epilepsy (RE). Here, we review the various cellular activities assigned to this complex and discuss the implications for neural development and disease. Further research in this area has the potential to generate new diagnostic tools, better prevention strategies and more effective treatment options for a wide variety of neurological disorders.
Keyword Elongator complex
Neurodevelopment
Neurological disorders
TRNA modifications
Translation
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: HERDC Pre-Audit
Institute for Molecular Bioscience - Publications
 
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