Accelerated mapping of magnetic susceptibility using 3D planes-on-a-paddlewheel (POP) EPI at ultra-high field strength

Stäb, Daniel, Bollmann, Steffen, Langkammer, Christian, Bredies, Kristian and Barth, Markus (2016) Accelerated mapping of magnetic susceptibility using 3D planes-on-a-paddlewheel (POP) EPI at ultra-high field strength. NMR in Biomedicine, 30 4: . doi:10.1002/nbm.3620

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Author Stäb, Daniel
Bollmann, Steffen
Langkammer, Christian
Bredies, Kristian
Barth, Markus
Title Accelerated mapping of magnetic susceptibility using 3D planes-on-a-paddlewheel (POP) EPI at ultra-high field strength
Journal name NMR in Biomedicine   Check publisher's open access policy
ISSN 0952-3480
1099-1492
Publication date 2016-10-20
Year available 2017
Sub-type Article (original research)
DOI 10.1002/nbm.3620
Open Access Status File (Author Post-print)
Volume 30
Issue 4
Total pages 12
Place of publication Chichester, United Kingdom
Publisher John Wiley & Sons
Language eng
Subject 1313 Molecular Medicine
2741 Radiology Nuclear Medicine and imaging
1607 Spectroscopy
Abstract With the advent of ultra-high field MRI scanners in clinical research, susceptibility based MRI has recently gained increasing interest because of its potential to assess subtle tissue changes underlying neurological pathologies/disorders. Conventional, but rather slow, three-dimensional (3D) spoiled gradient-echo (GRE) sequences are typically employed to assess the susceptibility of tissue. 3D echo-planar imaging (EPI) represents a fast alternative but generally comes with echo-time restrictions, geometrical distortions and signal dropouts that can become severe at ultra-high fields. In this work we assess quantitative susceptibility mapping (QSM) at 7T using non-Cartesian 3D EPI with a planes-on-a-paddlewheel (POP) trajectory, which is created by rotating a standard EPI readout train around its own phase encoding axis. We show that the threefold accelerated non-Cartesian 3D POP EPI sequence enables very fast, whole brain susceptibility mapping at an isotropic resolution of 1mm and that the high image quality has sufficient signal-to-noise ratio in the phase data for reliable QSM processing. The susceptibility maps obtained were comparable with regard to QSM values and geometric distortions to those calculated from a conventional 4min 3D GRE scan using the same QSM processing pipeline.
Keyword Brain
EPI
Non-Cartesian
Ultra-high field
Radial
QSM
Q-Index Code C1
Q-Index Status Provisional Code
Grant ID FT140100865
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: HERDC Pre-Audit
Centre for Advanced Imaging Publications
 
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Created: Sat, 26 Nov 2016, 01:41:00 EST by Daniel Staeb on behalf of Centre for Advanced Imaging