Cognitive neuroepigenetics: the next evolution in our understanding of the molecular mechanisms underlying learning and memory?

Marshall, Paul and Bredy, Timothy W. (2016) Cognitive neuroepigenetics: the next evolution in our understanding of the molecular mechanisms underlying learning and memory?. n p j Science of Learning, 16014. doi:10.1038/npjscilearn.2016.14


Author Marshall, Paul
Bredy, Timothy W.
Title Cognitive neuroepigenetics: the next evolution in our understanding of the molecular mechanisms underlying learning and memory?
Journal name n p j Science of Learning
ISSN 2056-7936
Publication date 2016-07-20
Year available 2016
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1038/npjscilearn.2016.14
Open Access Status DOI
Start page 16014
Total pages 8
Place of publication London, United Kingdom
Publisher Nature Publishing Group
Collection year 2017
Language eng
Abstract A complete understanding of the fundamental mechanisms of learning and memory continues to elude neuroscientists. Although many important discoveries have been made, the question of how memories are encoded and maintained at the molecular level remains. So far, this issue has been framed within the context of one of the most dominant concepts in molecular biology, the central dogma, and the result has been a protein-centric view of memory. Here, we discuss the evidence supporting a role for neuroepigenetic mechanisms, which constitute dynamic and reversible, state-dependent modifications at all levels of control over cellular function, and their role in learning and memory. This neuroepigenetic view suggests that DNA, RNA and protein each influence one another to produce a holistic cellular state that contributes to the formation and maintenance of memory, and predicts a parallel and distributed system for the consolidation, storage and retrieval of the engram.
Keyword Neuroepigenetics
Learning
Epitranscriptomics
Memory
Epigenetics
RNA editing
DNA modifications
DNA structure
DNA editing
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: HERDC Pre-Audit
Queensland Brain Institute Publications
 
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Created: Fri, 25 Nov 2016, 10:56:39 EST by Kirstie Asmussen on behalf of School of Music