The toll-like receptor 3 pathway in homeostasis, responses to injury and wound repair

Ramnath, Divya, Powell, Elizabeth E., Scholz, Glen M. and Sweet, Matthew J. (2016) The toll-like receptor 3 pathway in homeostasis, responses to injury and wound repair. Seminars in Cell and Developmental Biology, 61 22-30. doi:10.1016/j.semcdb.2016.08.014

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Author Ramnath, Divya
Powell, Elizabeth E.
Scholz, Glen M.
Sweet, Matthew J.
Title The toll-like receptor 3 pathway in homeostasis, responses to injury and wound repair
Journal name Seminars in Cell and Developmental Biology   Check publisher's open access policy
ISSN 1096-3634
Publication date 2016-01-01
Year available 2016
Sub-type Article (original research)
DOI 10.1016/j.semcdb.2016.08.014
Open Access Status File (Author Post-print)
Volume 61
Start page 22
End page 30
Total pages 9
Place of publication London, United Kingdom
Publisher Academic Press
Language eng
Subject 1309 Developmental Biology
1307 Cell Biology
Abstract In addition to their established roles in host defence, Toll-like Receptors (TLRs) have emerging roles in control of homeostasis, injury and wound repair. The dsRNA-sensing receptor, TLR3, has been particularly implicated in such processes in several different tissues including the skin, intestine and liver, as well as in the control of reparative mechanisms in the brain, heart and kidneys, following ischemia reperfusion injury. In this review, we provide an overview of TLR3 signalling and functions in inflammation, tissue damage and repair processes, as well as therapeutic opportunities that may arise in the future from knowledge of such pathways.
Keyword Toll-like receptor 3
Wound repair
Ischemia reperfusion injury
Q-Index Code C1
Q-Index Status Provisional Code
Grant ID ID628769
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
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