Functional magnetic porous silica for T1-T2 dual-modal magnetic resonance imaging and pH-responsive drug delivery of basic drugs

Li, Ling, Zhang, Run, Guo, Yi, Zhang, Cheng, Zhao, Wei, Xu, Zhiping and Whittaker, Andrew K. (2016) Functional magnetic porous silica for T1-T2 dual-modal magnetic resonance imaging and pH-responsive drug delivery of basic drugs. Nanotechnology, 27 48: . doi:10.1088/0957-4484/27/48/485702


Author Li, Ling
Zhang, Run
Guo, Yi
Zhang, Cheng
Zhao, Wei
Xu, Zhiping
Whittaker, Andrew K.
Title Functional magnetic porous silica for T1-T2 dual-modal magnetic resonance imaging and pH-responsive drug delivery of basic drugs
Formatted title
Functional magnetic porous silica for T1-T2 dual-modal magnetic resonance imaging and pH-responsive drug delivery of basic drugs
Journal name Nanotechnology   Check publisher's open access policy
ISSN 1361-6528
0957-4484
Publication date 2016-10-31
Sub-type Article (original research)
DOI 10.1088/0957-4484/27/48/485702
Open Access Status Not yet assessed
Volume 27
Issue 48
Total pages 7
Place of publication Bristol, United Kingdom
Publisher Institute of Physics Publishing
Language eng
Formatted abstract
A smart magnetic-targeting drug carrier γ-Fe2O3@p-silica comprising a γ-Fe2O3 core and porous shell has been prepared and characterized. The particles have a uniform size of about 60 nm, and a porous shell of thickness 3 nm. Abundant hydroxyl groups and a large surface area enabled the γ-Fe2O3@p-silica to be readily loaded with a large payload of the basic model drug rhodamine B (RB) (up to 73 mg g-1). Cytotoxicity assays of the γ-Fe2O3@p-silica particles indicated that the particles were biocompatible and suitable for carrying drugs. It was found that the RB was released rapidly at pH 5.5 but at pH 7.4 the rate and extent of release was greatly attenuated. The particles therefore demonstrate an excellent pH-triggered drug release. In addition, the γ-Fe2O3@p-silica particles could be tracked by magnetic resonance imaging (MRI). A clear dose-dependent contrast enhancement in both T1-weighted and T2-weighted MR images indicated the potential of the γ-Fe2O3@p-silica particles to act as dual-mode T1 and T2 MRI contrast agents.
Keyword Drug delivery
MRI-imaging
PH-responsive
Porous silica
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: HERDC Pre-Audit
Australian Institute for Bioengineering and Nanotechnology Publications
 
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