New insight in cold pain: role of ion channels, modulation, and clinical perspectives

Lolignier, Stéphane, Gkika, Dimitra, Andersson, David, Leipold, Enrico, Vetter, Irina, Viana, Felix, Noel, Jacques and Busserolles, Jérôme (2016) New insight in cold pain: role of ion channels, modulation, and clinical perspectives. The Journal of Neuroscience, 36 45: 1435-11439. doi:10.1523/JNEUROSCI.2327-16.2016

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Author Lolignier, Stéphane
Gkika, Dimitra
Andersson, David
Leipold, Enrico
Vetter, Irina
Viana, Felix
Noel, Jacques
Busserolles, Jérôme
Title New insight in cold pain: role of ion channels, modulation, and clinical perspectives
Journal name The Journal of Neuroscience   Check publisher's open access policy
ISSN 1529-2401
0270-6474
Publication date 2016-11-09
Year available 2016
Sub-type Article (original research)
DOI 10.1523/JNEUROSCI.2327-16.2016
Open Access Status File (Publisher version)
Volume 36
Issue 45
Start page 1435
End page 11439
Total pages 5
Place of publication Washington, DC, United States
Publisher Society for Neuroscience
Language eng
Abstract Cold temperature detection involves the process of sensory transduction in cutaneous primary sensory nerve terminals, which converts thermal stimuli into depolarizations of the membrane. This transformation into electrical signals is followed by the subsequent propagation of action potentials in cold-sensitive afferent nerve fibers. A large array of ion channels shapes this process; however, the precise contribution of specific ion channel subtypes to cold perception and cold pain remains elusive. This review aims at giving an update on our current understanding of the role played by TRPs, leak K(+) and voltage-gated Na(+) and K(+) channels in the transduction of cold by nociceptors and in cold-induced pain.
Formatted abstract
Cold temperature detection involves the process of sensory transduction in cutaneous primary sensory nerve terminals, which converts thermal stimuli into depolarizations of the membrane. This transformation into electrical signals is followed by the subsequent propagation of action potentials in cold-sensitive afferent nerve fibers. A large array of ion channels shapes this process; however, the precise contribution of specific ion channel subtypes to cold perception and cold pain remains elusive. This review aims at giving an update on our current understanding of the role played by TRPs, leak K+ and voltage-gated Na+ and K+ channels in the transduction of cold by nociceptors and in cold-induced pain.
Keyword Cold pain
Ion channels
Nociception
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: HERDC Pre-Audit
School of Pharmacy Publications
Institute for Molecular Bioscience - Publications
 
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