Centipede venoms as a source of drug leads

Undheim, Eivind A. B., Jenner, Ronald A. and King, Glenn F. (2016) Centipede venoms as a source of drug leads. Expert Opinion on Drug Discovery, 11 12: 1139-1149. doi:10.1080/17460441.2016.1235155


Author Undheim, Eivind A. B.
Jenner, Ronald A.
King, Glenn F.
Title Centipede venoms as a source of drug leads
Journal name Expert Opinion on Drug Discovery   Check publisher's open access policy
ISSN 1746-045X
1746-0441
Publication date 2016-12-01
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1080/17460441.2016.1235155
Open Access Status Not yet assessed
Volume 11
Issue 12
Start page 1139
End page 1149
Total pages 11
Place of publication Abingdon, Oxfordshire, United Kingdom
Publisher Taylor & Francis
Language eng
Formatted abstract
Introduction: Centipedes are one of the oldest and most successful lineages of venomous terrestrial predators. Despite their use for centuries in traditional medicine, centipede venoms remain poorly studied. However, recent work indicates that centipede venoms are highly complex chemical arsenals that are rich in disulfide-constrained peptides that have novel pharmacology and three-dimensional structure.

Areas covered: This review summarizes what is currently known about centipede venom proteins, with a focus on disulfide-rich peptides that have novel or unexpected pharmacology that might be useful from a therapeutic perspective. The authors also highlight the remarkable diversity of constrained three-dimensional peptide scaffolds present in these venoms that might be useful for bioengineering of drug leads.

Expert opinion: Like most arthropod predators, centipede venoms are rich in peptides that target neuronal ion channels and receptors, but it is also becoming increasingly apparent that many of these peptides have novel or unexpected pharmacological properties with potential applications in drug discovery and development.
Keyword Bioengineering
Biologic
Centipede venom
Drug discovery
Ion channel
Peptide drug
Therapeutic
Venom peptide
Venomics
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: HERDC Pre-Audit
Institute for Molecular Bioscience - Publications
Centre for Advanced Imaging Publications
 
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