Cryptic epitopes and functional diversity in extracellular proteins

Mortimer, Gysell M. and Minchin, Rodney F. (2016) Cryptic epitopes and functional diversity in extracellular proteins. International Journal of Biochemistry and Cell Biology, 81 Part A: 112-120. doi:10.1016/j.biocel.2016.10.020

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Author Mortimer, Gysell M.
Minchin, Rodney F.
Title Cryptic epitopes and functional diversity in extracellular proteins
Journal name International Journal of Biochemistry and Cell Biology   Check publisher's open access policy
ISSN 1878-5875
1357-2725
Publication date 2016-12-01
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1016/j.biocel.2016.10.020
Open Access Status File (Author Post-print)
Volume 81
Issue Part A
Start page 112
End page 120
Total pages 9
Place of publication Kidlington, Oxford, United Kingdom
Publisher Pergamon Press
Language eng
Abstract The functional diversity of proteins is a major factor determining the complexity of cells and tissues. Both translational and post-translational modifications contribute to this diversity. Recently, protein unfolding and refolding has been recognised as another mechanism for diversity by unmasking buried or cryptic sequences (epitopes) that possess physiological functions. In the current review, we focus on extracellular proteins where folding dynamics can be influenced by mechanical forces, protein-protein interactions and denaturation. Many cryptic epitopes in these proteins are exposed following proteolytic cleavage, but recent data indicate that unfolding/refolding play an important role in regulating the physiological behaviour of extracellular proteins. By understanding how and when hidden sequences are exposed, novel techniques for manipulating the function of these proteins may be uncovered.
Keyword Cryptic epitopes
Protein conformation
Protein unfolding
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: HERDC Pre-Audit
School of Biomedical Sciences Publications
 
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