Genetic and epigenetic factors underlying sex differences in the regulation of gene expression in the brain

Ratnu, Vikram S., Emami, Michael R. and Bredy, Timothy W. (2017) Genetic and epigenetic factors underlying sex differences in the regulation of gene expression in the brain. Journal of Neuroscience Research, 95 1-2: 301-310. doi:10.1002/jnr.23886


Author Ratnu, Vikram S.
Emami, Michael R.
Bredy, Timothy W.
Title Genetic and epigenetic factors underlying sex differences in the regulation of gene expression in the brain
Journal name Journal of Neuroscience Research   Check publisher's open access policy
ISSN 1097-4547
0360-4012
Publication date 2017-01-01
Year available 2016
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1002/jnr.23886
Open Access Status Not yet assessed
Volume 95
Issue 1-2
Start page 301
End page 310
Total pages 10
Place of publication Hoboken, NJ, United States
Publisher John Wiley & Sons
Collection year 2017
Language eng
Abstract There are inherent biological differences between males and females that contribute to sex differences in brain function and to many sex-specific illnesses and disorders. Traditionally, it has been thought that such differences are due largely to hormonal regulation; however, there are also genetic and epigenetic effects caused by the inheritance and unequal dosage of genes located on the X and Y chromosomes. Here we discuss the evidence in favor of a genetic and epigenetic basis for sexually dimorphic behavior, as a consequence of underlying differences in the regulation of genes that drive brain function. A better understanding of sex-specific molecular processes in the brain will provide further insight for the development of novel therapeutic approaches for the treatment of neuropsychiatric disorders characterized by sex differences.
Keyword Epigenetics
Regulation of gene expression
Sexually dimorphic behavior
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: HERDC Pre-Audit
Queensland Brain Institute Publications
 
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