The distribution of Ki-67 and doublecortin immunopositive cells in the brains of three microchiropteran species, Hipposideros fuliginosus, Triaenops persicus, and Asellia tridens

Chawana, Richard, Patzke, Nina, Alagaili, Abdulaziz N., Bennett, Nigel C., Mohammed, Osama B., Kaswera-Kyamakya, Consolate, Gilissen, Emmanuel, Ihunwo, Amadi O., Pettigrew, John D. and Manger, Paul R. (2016) The distribution of Ki-67 and doublecortin immunopositive cells in the brains of three microchiropteran species, Hipposideros fuliginosus, Triaenops persicus, and Asellia tridens. Anatomical Record, 299 11: 1548-1560. doi:10.1002/ar.23460


Author Chawana, Richard
Patzke, Nina
Alagaili, Abdulaziz N.
Bennett, Nigel C.
Mohammed, Osama B.
Kaswera-Kyamakya, Consolate
Gilissen, Emmanuel
Ihunwo, Amadi O.
Pettigrew, John D.
Manger, Paul R.
Title The distribution of Ki-67 and doublecortin immunopositive cells in the brains of three microchiropteran species, Hipposideros fuliginosus, Triaenops persicus, and Asellia tridens
Formatted title
The distribution of Ki-67 and doublecortin immunopositive cells in the brains of three microchiropteran species, Hipposideros fuliginosus, Triaenops persicus, and Asellia tridens
Journal name Anatomical Record   Check publisher's open access policy
ISSN 1932-8494
1932-8486
Publication date 2016-11-01
Sub-type Article (original research)
DOI 10.1002/ar.23460
Open Access Status Not yet assessed
Volume 299
Issue 11
Start page 1548
End page 1560
Total pages 13
Place of publication Hoboken, NJ, United States
Publisher John Wiley & Sons
Language eng
Subject 2702 Anatomy
1305 Biotechnology
2722 Histology
1105 Ecology, Evolution, Behavior and Systematics
Abstract This study uses Ki-67 and doublecortin (DCX) immunohistochemistry to delineate potential neurogenic zones, migratory pathways, and terminal fields associated with adult neurogenesis in the brains of three microchiropterans. As with most mammals studied to date, the canonical subgranular and subventricular neurogenic zones were observed. Distinct labeling of newly born cells and immature neurons within the dentate gyrus of the hippocampus was observed in all species. A distinct rostral migratory stream (RMS) that appears to split around the medial aspect of the caudate nucleus was observed. These two rostral stream divisions appear to merge at the rostroventral corner of the caudate nucleus to turn and enter the olfactory bulb, where a large terminal field of immature neurons was observed. DCX immunolabeled neurons were observed mostly in the rostral neocortex, but a potential migratory stream to the neocortex was not identified. A broad swathe of newly born cells and immature neurons was found between the caudoventral division of the RMS and the piriform cortex. In addition, occasional immature neurons were observed in the amygdala and DCX-immunopositive axons were observed in the anterior commissure. While the majority of these features have been found in several mammal species, the large number of DCX immunolabeled cells found between the RMS and the piriform cortex and the presence of DCX immunostained axons in the anterior commissure are features only observed in microchiropterans and insectivores to date. In the diphyletic scenario of chiropteran evolution, these observations align the microchiropterans with the insectivores.
Keyword Adult neurogenesis
Anterior commissure
Chiroptera
Doublecortin
Hippocampus
Ki-67
Piriform cortex
Wild-living animals
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: HERDC Pre-Audit
Queensland Brain Institute Publications
 
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