Frailty and chronic kidney disease: a systematic review

Chowdhury, Rakin, Peel, Nancye M., Krosch, Mitchell and Hubbard, Ruth E. (2017) Frailty and chronic kidney disease: a systematic review. Archives of Gerontology and Geriatrics, 68 135-142. doi:10.1016/j.archger.2016.10.007

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Author Chowdhury, Rakin
Peel, Nancye M.
Krosch, Mitchell
Hubbard, Ruth E.
Title Frailty and chronic kidney disease: a systematic review
Journal name Archives of Gerontology and Geriatrics   Check publisher's open access policy
ISSN 1872-6976
0167-4943
Publication date 2017-01-01
Year available 2016
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1016/j.archger.2016.10.007
Open Access Status File (Author Post-print)
Volume 68
Start page 135
End page 142
Total pages 8
Place of publication E Park, Shannon, Clare Ireland
Publisher Elsevier Ireland
Collection year 2018
Language eng
Formatted abstract
Objective: Frailty is associated with increased vulnerability to poor health. There is growing interest in understanding the association between frailty and chronic kidney disease (CKD). This systematic review explored how frailty is measured in patients with CKD and the association between frailty and adverse outcomes across different stages of renal impairment.

Study design: Systematic analysis of peer reviewed articles.

Data sources: Pubmed, Medline, Web of Science and Cochrane were used to identify the articles.

Data synthesis: Articles published before the 17th of September 2016, that measured frailty in patients with CKD was eligible for the systematic review. Two independent researchers assessed the eligibility of the articles. Quality of the articles was assessed using the Epidemiological Appraisal Instrument.

Results: The literature search yielded 540 articles, of which 32 met the study criteria and were included in the review (n = 36,076, age range: 50–83 years). Twenty-three (72%) studies used or adapted the Fried phenotype to measure frailty. The prevalence of frailty ranged from 7% in community-dwellers (CKD Stages 1–4) to 73% in a cohort of patients on haemodialysis. The incidence of frailty increased with reduced glomerular filtration rate. Frailty was associated with an increased risk of mortality and hospitalization.

Conclusion: Frailty is prevalent in patients with CKD and it is associated with an increased risk of adverse health outcomes. There are differences in the methods used to assess frailty and this hinders comparisons between studies.
Keyword Chronic
Frail elderly
Renal insufficiency
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: HERDC Pre-Audit
Centre for Research in Geriatric Medicine Publications
 
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