Comparison of magnetic resonance imaging and computed tomography for breast target volume delineation in prone and supine positions

Pogson, Elise M., Delaney, Geoff P., Ahern, Verity, Boxer, Miriam M., Chan, Christine, David, Steven, Dimigen, Marion, Harvey, Jennifer A., Koh, Eng-Siew, Lim, Karen, Papadatos, George, Yap, Mei Ling, Batumalai, Vikneswary, Lazarus, Elizabeth, Dundas, Kylie, Shafiq, Jesmin, Liney, Gary, Moran, Catherine, Metcalfe, Peter and Holloway, Lois (2016) Comparison of magnetic resonance imaging and computed tomography for breast target volume delineation in prone and supine positions. International Journal of Radiation Oncology - Biology - Physics, 96 4: 905-912. doi:10.1016/j.ijrobp.2016.08.002

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Author Pogson, Elise M.
Delaney, Geoff P.
Ahern, Verity
Boxer, Miriam M.
Chan, Christine
David, Steven
Dimigen, Marion
Harvey, Jennifer A.
Koh, Eng-Siew
Lim, Karen
Papadatos, George
Yap, Mei Ling
Batumalai, Vikneswary
Lazarus, Elizabeth
Dundas, Kylie
Shafiq, Jesmin
Liney, Gary
Moran, Catherine
Metcalfe, Peter
Holloway, Lois
Title Comparison of magnetic resonance imaging and computed tomography for breast target volume delineation in prone and supine positions
Journal name International Journal of Radiation Oncology - Biology - Physics   Check publisher's open access policy
ISSN 1879-355X
Publication date 2016-11-15
Sub-type Article (original research)
DOI 10.1016/j.ijrobp.2016.08.002
Open Access Status File (Author Post-print)
Volume 96
Issue 4
Start page 905
End page 912
Total pages 8
Place of publication Philadelphia, PA, United States
Publisher Elsevier
Collection year 2017
Language eng
Formatted abstract
Purpose: To determine whether T2-weighted MRI improves seroma cavity (SC) and whole breast (WB) interobserver conformity for radiation therapy purposes, compared with the gold standard of CT, both in the prone and supine positions.

Methods and Materials:
Eleven observers (2 radiologists and 9 radiation oncologists) delineated SC and WB clinical target volumes (CTVs) on T2-weighted MRI and CT supine and prone scans (4 scans per patient) for 33 patient datasets. Individual observer's volumes were compared using the Dice similarity coefficient, volume overlap index, center of mass shift, and Hausdorff distances. An average cavity visualization score was also determined.

Results: Imaging modality did not affect interobserver variation for WB CTVs. Prone WB CTVs were larger in volume and more conformal than supine CTVs (on both MRI and CT). Seroma cavity volumes were larger on CT than on MRI. Seroma cavity volumes proved to be comparable in interobserver conformity in both modalities (volume overlap index of 0.57 (95% Confidence Interval (CI) 0.54-0.60) for CT supine and 0.52 (95% CI 0.48-0.56) for MRI supine, 0.56 (95% CI 0.53-0.59) for CT prone and 0.55 (95% CI 0.51-0.59) for MRI prone); however, after registering modalities together the intermodality variation (Dice similarity coefficient of 0.41 (95% CI 0.36-0.46) for supine and 0.38 (0.34-0.42) for prone) was larger than the interobserver variability for SC, despite the location typically remaining constant.

Conclusions: Magnetic resonance imaging interobserver variation was comparable to CT for the WB CTV and SC delineation, in both prone and supine positions. Although the cavity visualization score and interobserver concordance was not significantly higher for MRI than for CT, the SCs were smaller on MRI, potentially owing to clearer SC definition, especially on T2-weighted MR images.
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Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
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