Caveolin-1 function in liver physiolocy and disease

Fernandez-Rojo, Manuel A. and Ramm, Grant A. (2016) Caveolin-1 function in liver physiolocy and disease. Trends in Molecular Medicine, 22 10: 889-904. doi:10.1016/j.molmed.2016.08.007

Author Fernandez-Rojo, Manuel A.
Ramm, Grant A.
Title Caveolin-1 function in liver physiolocy and disease
Journal name Trends in Molecular Medicine   Check publisher's open access policy
ISSN 1471-4914
Publication date 2016-10-01
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1016/j.molmed.2016.08.007
Open Access Status Not yet assessed
Volume 22
Issue 10
Start page 889
End page 904
Total pages 16
Place of publication Kidlington, Oxford, United Kingdom
Publisher Elsevier
Language eng
Subject 1313 Molecular Medicine
1312 Molecular Biology
Abstract Caveolin-1 (CAV1), the structural protein of caveolae in the plasma membrane, has emerged as a regulator of liver function. CAV1 modulates several molecular pathways leading to the regulation of hepatic lipid accumulation, lipid and glucose metabolism, mitochondrial biology, and hepatocyte proliferation. CAV1 thus plays a crucial role in maintaining hepatic physiology during metabolic adaptation to fasting, liver steatosis, and hepatocyte proliferation associated with liver regeneration. With failure of such processes, CAV1 has been implicated in the modulation of cholestasis, hepatitis, cirrhosis, and hepatocarcinogenesis. This review discusses the latest research in CAV1 biology and related proteins, aiming to guide future endeavors that explore their role in liver physiology and disease.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
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