An evaluation of the use of topical tranexamic acid in total knee arthroplasty

Chimento, George F., Huff, Tamara, Ochsner, J. Lockwood, Jr., Meyer, Mark, Brandner, Luci and Babin, Sheena (2013) An evaluation of the use of topical tranexamic acid in total knee arthroplasty. Journal of Arthroplasty, 28 8 SUPPL: 74-77. doi:10.1016/j.arth.2013.06.037

Author Chimento, George F.
Huff, Tamara
Ochsner, J. Lockwood, Jr.
Meyer, Mark
Brandner, Luci
Babin, Sheena
Title An evaluation of the use of topical tranexamic acid in total knee arthroplasty
Journal name Journal of Arthroplasty   Check publisher's open access policy
ISSN 0883-5403
Publication date 2013-09-01
Year available 2013
Sub-type Article (original research)
DOI 10.1016/j.arth.2013.06.037
Open Access Status Not yet assessed
Volume 28
Issue 8 SUPPL
Start page 74
End page 77
Total pages 4
Place of publication Philadelphia, PA, United States
Publisher Churchill Livingstone
Language eng
Formatted abstract
The purpose of this study was to evaluate the effectiveness of topical tranexamic acid in primary TKA from a clinical and economic standpoint. We retrospectively reviewed 683 primary total knee arthroplasties performed at a single institution over a 2-year period. We compared 373 cases performed in 2010 without tranexamic acid to 310 cases performed in 2011 with tranexamic acid. Demographic data, hemoglobin levels, transfusion rates, hospital length of stay, cost, and perioperative complications during the first 3. months were collected. Statistical analysis was performed using two sample t-tests and Fisher's exact tests. There was no difference in age, sex, height, or pre-operative hemoglobin between the two groups. The tranexamic acid group had significantly higher post-operative hemoglobin ( p < 0.0001), lower transfusion rate (P < 0.0001), decreased length of stay (P < 0.0001), decreased blood bank costs (P < 0.0001), increased pharmacy cost (P < 0.0001), and decreased total direct cost to the hospital (P < 0.0001). The average savings was approximately $1500 per patient. There were no differences in thromboembolic events or infection. The use topical tranexamic acid in primary TKA is safe, effective, and results in significant cost savings.
Keyword Blood product management
Knee replacement
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Medicine Publications
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 39 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 46 times in Scopus Article | Citations
Google Scholar Search Google Scholar
Created: Sat, 12 Nov 2016, 05:30:24 EST by System User on behalf of Learning and Research Services (UQ Library)