A three-stage intrathymic development pathway for the mucosal-associated invariant T cell lineage

Koay, Hui-Fern, Gherardin, Nicholas A., Enders, Anselm, Loh, Liyen, Mackay, Laura K., Almeida, Catarina F., Russ, Brendan E., Nold-Petry, Claudia A., Nold, Marcel F., Bedoui, Sammy, Chen, Zhenjun, Corbett, Alexandra J., Eckle, Sidonia B. G., Meehan, Bronwyn, D'Udekem, Yves, Konstantinov, Igor E., Lappas, Martha, Liu, Ligong, Goodnow, Chris C., Fairlie, David P., Rossjohn, Jamie, Chong, Mark M., Kedzierska, Katherine, Berzins, Stuart P., Belz, Gabrielle T., McCluskey, James, Uldrich, Adam P., Godfrey, Dale I. and Pellicci, Daniel G. (2016) A three-stage intrathymic development pathway for the mucosal-associated invariant T cell lineage. Nature Immunology, 17 11: 1300-1311. doi:10.1038/ni.3565

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Author Koay, Hui-Fern
Gherardin, Nicholas A.
Enders, Anselm
Loh, Liyen
Mackay, Laura K.
Almeida, Catarina F.
Russ, Brendan E.
Nold-Petry, Claudia A.
Nold, Marcel F.
Bedoui, Sammy
Chen, Zhenjun
Corbett, Alexandra J.
Eckle, Sidonia B. G.
Meehan, Bronwyn
D'Udekem, Yves
Konstantinov, Igor E.
Lappas, Martha
Liu, Ligong
Goodnow, Chris C.
Fairlie, David P.
Rossjohn, Jamie
Chong, Mark M.
Kedzierska, Katherine
Berzins, Stuart P.
Belz, Gabrielle T.
McCluskey, James
Uldrich, Adam P.
Godfrey, Dale I.
Pellicci, Daniel G.
Title A three-stage intrathymic development pathway for the mucosal-associated invariant T cell lineage
Journal name Nature Immunology   Check publisher's open access policy
ISSN 1529-2916
Publication date 2016-11-01
Year available 2016
Sub-type Article (original research)
DOI 10.1038/ni.3565
Open Access Status File (Author Post-print)
Volume 17
Issue 11
Start page 1300
End page 1311
Total pages 12
Place of publication New York, NY, United States
Publisher Nature Publishing Group
Language eng
Subject 2403 Immunology
Abstract Mucosal-associated invariant T cells (MAIT cells) detect microbial vitamin B2 derivatives presented by the antigen-presenting molecule MR1. Here we defined three developmental stages and checkpoints for the MAIT cell lineage in humans and mice. Stage 1 and stage 2 MAIT cells predominated in thymus, while stage 3 cells progressively increased in abundance extrathymically. Transition through each checkpoint was regulated by MR1, whereas the final checkpoint that generated mature functional MAIT cells was controlled by multiple factors, including the transcription factor PLZF and microbial colonization. Furthermore, stage 3 MAIT cell populations were expanded in mice deficient in the antigen-presenting molecule CD1d, suggestive of a niche shared by MAIT cells and natural killer T cells (NKT cells). Accordingly, this study maps the developmental pathway and checkpoints that control the generation of functional MAIT cells.
Keyword Mait Cells
Receptor Heterogeneity
Mr1 Tetramers
Q-Index Code C1
Q-Index Status Provisional Code
Grant ID 1083942
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: HERDC Pre-Audit
Institute for Molecular Bioscience - Publications
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Citation counts: TR Web of Science Citation Count  Cited 27 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 31 times in Scopus Article | Citations
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