The dynamics of functional brain networks: integrated network states during cognitive task performance

Shine, James M., Bissett, Patrick G., Bell, Peter T., Koyejo, Oluwasanmi, Balsters, Joshua H., Gorgolewski, Krzysztof J., Moodie, Craig A. and Poldrack, Russell A. (2016) The dynamics of functional brain networks: integrated network states during cognitive task performance. Neuron, 92 2: 544-554. doi:10.1016/j.neuron.2016.09.018


Author Shine, James M.
Bissett, Patrick G.
Bell, Peter T.
Koyejo, Oluwasanmi
Balsters, Joshua H.
Gorgolewski, Krzysztof J.
Moodie, Craig A.
Poldrack, Russell A.
Title The dynamics of functional brain networks: integrated network states during cognitive task performance
Journal name Neuron   Check publisher's open access policy
ISSN 1097-4199
0896-6273
Publication date 2016-10-19
Sub-type Article (original research)
DOI 10.1016/j.neuron.2016.09.018
Open Access Status Not yet assessed
Volume 92
Issue 2
Start page 544
End page 554
Total pages 11
Place of publication Cambridge, MA, United States
Publisher Cell Press
Language eng
Abstract Higher brain function relies upon the ability to flexibly integrate information across specialized communities of brain regions; however, it is unclear how this mechanism manifests over time. In this study, we used time-resolved network analysis of fMRI data to demonstrate that the human brain traverses between functional states that maximize either segregation into tight-knit communities or integration across otherwise disparate neural regions. Integrated states enable faster and more accurate performance on a cognitive task, and are associated with dilations in pupil diameter, suggesting that ascending neuromodulatory systems may govern the transition between these alternative modes of brain function. Together, our results confirm a direct link between cognitive performance and the dynamic reorganization of the network structure of the brain.
Q-Index Code C1
Q-Index Status Provisional Code
Grant ID F32 DA041773
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: UQ Centre for Clinical Research Publications
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Citation counts: TR Web of Science Citation Count  Cited 11 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 15 times in Scopus Article | Citations
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