The role of microRNAs in cerebellar development and autism spectrum disorder during embryogenesis

Constantin, Lena (2017) The role of microRNAs in cerebellar development and autism spectrum disorder during embryogenesis. Molecular Neurobiology, 54 9: 6944-6959. doi:10.1007/s12035-016-0220-9


Author Constantin, Lena
Title The role of microRNAs in cerebellar development and autism spectrum disorder during embryogenesis
Journal name Molecular Neurobiology   Check publisher's open access policy
ISSN 1559-1182
0893-7648
Publication date 2017-11-01
Year available 2017
Sub-type Article (original research)
DOI 10.1007/s12035-016-0220-9
Open Access Status Not yet assessed
Volume 54
Issue 9
Start page 6944
End page 6959
Total pages 16
Place of publication Heidelberg, Germany
Publisher Springer
Language eng
Subject 2804 Cellular and Molecular Neuroscience
Abstract MicroRNAs (miRNAs) are a class of small non-coding RNA molecules with wide-ranging and subtle effects on protein production. Their activity during the development of the cerebellum provides a valuable exemplar of how non-coding molecules may assist the development and function of the central nervous system and drive neurodevelopmental disorders. Three distinct aspects of miRNA contribution to early cerebellar development will here be reviewed. Aspects are the establishment of the cerebellar anlage, the generation and maturation of at least two principal cell types of the developing cerebellar microcircuit, and the etiology and early progression of autism spectrum disorder. It will be argued here that the autism spectrum is an adept model to explore miRNA impact on the cognitive and affective processes that descend from the developing cerebellum.
Keyword Autism spectrum disorder
Bergmann glia
Cerebellum
Dicer
Embryonic development
Granule cell progenitor
MicroRNA
Midbrain-hindbrain boundary
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: HERDC Pre-Audit
School of Biomedical Sciences Publications
Institute for Molecular Bioscience - Publications
 
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