'Omics approaches in breast cancer research and clinical practice

Kalita-De Croft, Priyakshi, Al-Ejeh, Fares, McCart Reed, Amy E., Saunus, Jodi M. and Lakhani, Sunil R. (2016) 'Omics approaches in breast cancer research and clinical practice. Advances in Anatomic Pathology, 23 6: 356-367. doi:10.1097/PAP.0000000000000128

Author Kalita-De Croft, Priyakshi
Al-Ejeh, Fares
McCart Reed, Amy E.
Saunus, Jodi M.
Lakhani, Sunil R.
Title 'Omics approaches in breast cancer research and clinical practice
Journal name Advances in Anatomic Pathology   Check publisher's open access policy
ISSN 1533-4031
Publication date 2016-11-01
Year available 2016
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1097/PAP.0000000000000128
Open Access Status Not yet assessed
Volume 23
Issue 6
Start page 356
End page 367
Total pages 12
Place of publication Philadelphia, PA, United States
Publisher Lippincott Williams & Wilkins
Language eng
Abstract Our understanding of the natural history of breast cancer has evolved alongside technologies to study its genomic, transcriptomic, proteomic, and metabolomics landscapes. These technologies have helped decipher multiple molecular pathways dysregulated in breast cancer. First-generation 'omics analyses considered each of these dimensions individually, but it is becoming increasingly clear that more holistic, integrative approaches are required to fully understand complex biological systems. The 'omics represent an exciting era of discovery in breast cancer research, although important issues need to be addressed to realize the clinical utility of these data through precision cancer care. How can the data be applied to predict response to molecular-targeted therapies? When should treatment decisions be based on tumor genetics rather than histology? And with the sudden explosion of "big data" from large 'omics consortia and new precision clinical trials, how do we now negotiate evidence-based pathways to clinical translation through this apparent sea of opportunity? The aim of this review is to provide a broad overview of 'omics technologies used in breast cancer research today, the current state-of-play in terms of applying this new knowledge in the clinic, and the practical and ethical issues that will be central to the public discussion on the future of precision cancer care.
Keyword Breast cancer
Precision medicine
Q-Index Code C1
Q-Index Status Provisional Code
Grant ID 1017028
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: UQ Centre for Clinical Research Publications
HERDC Pre-Audit
Admin Only - School of Medicine
School of Medicine Publications
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 4 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 5 times in Scopus Article | Citations
Google Scholar Search Google Scholar
Created: Tue, 08 Nov 2016, 10:39:36 EST by System User on behalf of Learning and Research Services (UQ Library)