The bistratenes: new cytotoxic marine macrolides which induce some properties indicative of differentiation in HL-60 cells

Watters, D, Marshall, K, Hamilton, S, Michael, J, McArthur, M, Seymour, G, Hawkins, C, Gardiner, R and Lavin, M (1990) The bistratenes: new cytotoxic marine macrolides which induce some properties indicative of differentiation in HL-60 cells. Biochemical Pharmacology, 39 10: 1609-1614. doi:10.1016/0006-2952(90)90528-S


Author Watters, D
Marshall, K
Hamilton, S
Michael, J
McArthur, M
Seymour, G
Hawkins, C
Gardiner, R
Lavin, M
Title The bistratenes: new cytotoxic marine macrolides which induce some properties indicative of differentiation in HL-60 cells
Journal name Biochemical Pharmacology   Check publisher's open access policy
ISSN 0006-2952
Publication date 1990-05-15
Sub-type Article (original research)
DOI 10.1016/0006-2952(90)90528-S
Volume 39
Issue 10
Start page 1609
End page 1614
Total pages 6
Language eng
Subject 3004 Pharmacology
Abstract The biological effects of cytotoxic macrolide polyethers, the bistratenes, isolated from the ascidian Lissoclinum bistratum, have been examined. Bistratenc A was toxic to HL-60 human promyelocytic leukemia cells with an ic50 value of 424 nM. At lower concentrations (10-100 nM), bistratene A induced the incomplete differentiation of these cells along the monocyte/macrophage pathway. These effects were not due to inhibition of DNA synthesis. Bistratene B had similar effects to bistratene A. At micromolar concentrations these compounds enhance the phospholipid-dependent activity of type II protein kinase C from bovine spleen. The bistratenes provide new probes for studying the molecular mechanisms governing cell growth and differentiation.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
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