THE ADVERSE EFFECT OF FIBRIN‐CLOT INHIBITING DRUGS ON INTRAVESICAL BACILLUS CALMETTE‐GUÉRIN EFFICACY FOR SUPERFICIAL BLADDER CANCER

Png, Kbf, Walsh, MD, Seymour, GJ, Lavin, MF and Gardiner, RA (1993) THE ADVERSE EFFECT OF FIBRIN‐CLOT INHIBITING DRUGS ON INTRAVESICAL BACILLUS CALMETTE‐GUÉRIN EFFICACY FOR SUPERFICIAL BLADDER CANCER. Australian and New Zealand Journal of Surgery, 63 2: 127-130. doi:10.1111/j.1445-2197.1993.tb00060.x


Author Png, Kbf
Walsh, MD
Seymour, GJ
Lavin, MF
Gardiner, RA
Title THE ADVERSE EFFECT OF FIBRIN‐CLOT INHIBITING DRUGS ON INTRAVESICAL BACILLUS CALMETTE‐GUÉRIN EFFICACY FOR SUPERFICIAL BLADDER CANCER
Journal name Australian and New Zealand Journal of Surgery   Check publisher's open access policy
ISSN 1445-2197
Publication date 1993-01-01
Year available 1993
Sub-type Article (original research)
DOI 10.1111/j.1445-2197.1993.tb00060.x
Open Access Status Not yet assessed
Volume 63
Issue 2
Start page 127
End page 130
Total pages 4
Place of publication CARLTON
Publisher BLACKWELL SCIENCE
Language eng
Subject 2746 Surgery
Abstract Bacillus Calmette‐Guérin (BCG) is currently thought to act as a biological immune modifier in effecting antitumour activity. Recent evidence suggests that BCG binding to fibronectin (FN), a tissue glycoprotein, may be a prerequisite step in initiating this response. Drugs inhibiting the availability of exposed FN in the bladder after urothelial disruption may adversely affect the efficacy of BCG. Data are presented of 45 patients with tumour limited to mucosa (pTa) or carcinoma in situ (CIS) given intravesical BCG therapy, with (group 1) or without (group 2) fibrin clot‐inhibiting drugs concurrently during treatment. The success rate of 11.1 % for group 1 ((1/9) patients was significantly less than that of 69.4% for group 2 (25/36). (x2= 7.79. P 0.01 Fisher's exact test) supporting the suggestion that the concurrent administration of fibrin‐clot inhibiting drugs may adversely affect the outcome of BCG therapy. Copyright
Keyword bacillus Calmette‐Guérin
bladder cancer
fibronectin
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collections: ResearcherID Downloads - Archived
Scopus Import - Archived
 
Versions
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 10 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 9 times in Scopus Article | Citations
Google Scholar Search Google Scholar
Created: Thu, 03 Nov 2016, 23:00:50 EST by System User