Cross-national epidemiology of panic disorder and panic attacks in the world mental health surveys

de Jonge, Peter, Roest, Annelieke, Lim, Carmen C. W., Florescu, Silvia E., Bromet, Evelyn J., Stein, Dan J., Harris, Meredith, Nakov, Vladimir, Caldas-de-Almeida, Jose Miguel, Levinson, Daphna, Al-Hamzawi, Ali O., Haro, Josep Maria, Viana, Maria Carmen, Borges, Guilherme, O'Neill, Siobhan, de Girolamo, Giovanni, Demyttenaere, Koen, Gureke, Oye, Iwata, Noboru, Lee, Sing, Hu, Chiyi, Karam, Aimee, Moskalewicz, Jacek, Kovess-Masfety, Viviane, Navarro-Mateu, Fernando, Browne, Mark Oakley, Piazza, Marina, Posada-Villa, Jose, Torres, Yolanda and Scott, Kate M. (2016) Cross-national epidemiology of panic disorder and panic attacks in the world mental health surveys. Depression and Anxiety, 33 12: 1155-1177. doi:10.1002/da.22572

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Author de Jonge, Peter
Roest, Annelieke
Lim, Carmen C. W.
Florescu, Silvia E.
Bromet, Evelyn J.
Stein, Dan J.
Harris, Meredith
Nakov, Vladimir
Caldas-de-Almeida, Jose Miguel
Levinson, Daphna
Al-Hamzawi, Ali O.
Haro, Josep Maria
Viana, Maria Carmen
Borges, Guilherme
O'Neill, Siobhan
de Girolamo, Giovanni
Demyttenaere, Koen
Gureke, Oye
Iwata, Noboru
Lee, Sing
Hu, Chiyi
Karam, Aimee
Moskalewicz, Jacek
Kovess-Masfety, Viviane
Navarro-Mateu, Fernando
Browne, Mark Oakley
Piazza, Marina
Posada-Villa, Jose
Torres, Yolanda
Scott, Kate M.
Title Cross-national epidemiology of panic disorder and panic attacks in the world mental health surveys
Journal name Depression and Anxiety   Check publisher's open access policy
ISSN 1091-4269
1520-6394
Publication date 2016-10-24
Sub-type Article (original research)
DOI 10.1002/da.22572
Open Access Status Not yet assessed
Volume 33
Issue 12
Start page 1155
End page 1177
Total pages 23
Place of publication Hoboken, NJ, United States
Publisher John Wiley & Sons
Language eng
Subject 3203 Clinical Psychology
2738 Psychiatry and Mental health
Abstract Context: The scarcity of cross-national reports and the changes in Diagnostic and Statistical Manual version 5 (DSM-5) regarding panic disorder (PD) and panic attacks (PAs) call for new epidemiological data on PD and PAs and its subtypes in the general population. Objective: To present representative data about the cross-national epidemiology of PD and PAs in accordance with DSM-5 definitions. Design and setting: Nationally representative cross-sectional surveys using the World Health Organization Composite International Diagnostic Interview version 3.0. Participants: Respondents (n = 142,949) from 25 high, middle, and lower-middle income countries across the world aged 18 years or older. Main outcome measures: PD and presence of single and recurrent PAs. Results: Lifetime prevalence of PAs was 13.2% (SE 0.1%). Among persons that ever had a PA, the majority had recurrent PAs (66.5%; SE 0.5%), while only 12.8% fulfilled DSM-5 criteria for PD. Recurrent PAs were associated with a subsequent onset of a variety of mental disorders (OR 2.0; 95% CI 1.8–2.2) and their course (OR 1.3; 95% CI 1.2–2.4) whereas single PAs were not (OR 1.1; 95% CI 0.9–1.3 and OR 0.7; 95% CI 0.6–0.8). Cross-national lifetime prevalence estimates were 1.7% (SE 0.0%) for PD with a median age of onset of 32 (IQR 20–47). Some 80.4% of persons with lifetime PD had a lifetime comorbid mental disorder. Conclusions: We extended previous epidemiological data to a cross-national context. The presence of recurrent PAs in particular is associated with subsequent onset and course of mental disorders beyond agoraphobia and PD, and might serve as a generic risk marker for psychopathology.
Formatted abstract
Context: The scarcity of cross-national reports and the changes in Diagnostic and Statistical Manual version 5 (DSM-5) regarding panic disorder (PD) and panic attacks (PAs) call for new epidemiological data on PD and PAs and its subtypes in the general population.

Objective: To present representative data about the cross-national epidemiology of PD and PAs in accordance with DSM-5 definitions.

Design and setting: Nationally representative cross-sectional surveys using the World Health Organization Composite International Diagnostic Interview version 3.0.

Participants: Respondents (n = 142,949) from 25 high, middle, and lower-middle income countries across the world aged 18 years or older.

Main outcome measures: PD and presence of single and recurrent PAs.

Results: Lifetime prevalence of PAs was 13.2% (SE 0.1%). Among persons that ever had a PA, the majority had recurrent PAs (66.5%; SE 0.5%), while only 12.8% fulfilled DSM-5 criteria for PD. Recurrent PAs were associated with a subsequent onset of a variety of mental disorders (OR 2.0; 95% CI 1.8–2.2) and their course (OR 1.3; 95% CI 1.2–2.4) whereas single PAs were not (OR 1.1; 95% CI 0.9–1.3 and OR 0.7; 95% CI 0.6–0.8). Cross-national lifetime prevalence estimates were 1.7% (SE 0.0%) for PD with a median age of onset of 32 (IQR 20–47). Some 80.4% of persons with lifetime PD had a lifetime comorbid mental disorder.

Conclusions: We extended previous epidemiological data to a cross-national context. The presence of recurrent PAs in particular is associated with subsequent onset and course of mental disorders beyond agoraphobia and PD, and might serve as a generic risk marker for psychopathology.
Keyword Anxiety/anxiety disorders
Assessment/diagnosis
Epidemiology
International
Panic attacks/agoraphobia
Q-Index Code C1
Q-Index Status Provisional Code
Grant ID R01 DA016558
R03 TW006481
R01 MH069864
R01 MH061905
U01 MH060220
R01 MH070884
R01 MH059575
R13 MH066849
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: HERDC Pre-Audit
Queensland Brain Institute Publications
School of Public Health Publications
 
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Created: Thu, 03 Nov 2016, 09:15:52 EST by Carmen Lim on behalf of School of Public Health