Toward laboratory blood test-comparable photometric assessments for anemia in veterinary hematology

Kim, Taehoon, Choi, Seung Ho, Lambert-Cheatham, Nathan, Xu, Zhengbin, Kritchevsky, Janice E., Bertin, Francois-Rene and Kim, Young L. (2016) Toward laboratory blood test-comparable photometric assessments for anemia in veterinary hematology. Journal of Biomedical Optics, 21 10: 107001-1-107001-9. doi:10.1117/1.JBO.21.10.107001

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Author Kim, Taehoon
Choi, Seung Ho
Lambert-Cheatham, Nathan
Xu, Zhengbin
Kritchevsky, Janice E.
Bertin, Francois-Rene
Kim, Young L.
Title Toward laboratory blood test-comparable photometric assessments for anemia in veterinary hematology
Journal name Journal of Biomedical Optics   Check publisher's open access policy
ISSN 1560-2281
1083-3668
Publication date 2016-10-05
Year available 2016
Sub-type Article (original research)
DOI 10.1117/1.JBO.21.10.107001
Open Access Status File (Publisher version)
Volume 21
Issue 10
Start page 107001-1
End page 107001-9
Total pages 9
Place of publication Bellingham, WA United States
Publisher SPIE
Language eng
Subject 2504 Electronic, Optical and Magnetic Materials
2502 Biomaterials
3107 Atomic and Molecular Physics, and Optics
2204 Biomedical Engineering
Abstract Anemia associated with intestinal parasites and malnutrition is the leading cause of morbidity and mortality in small ruminants worldwide. Qualitative scoring of conjunctival redness has been developed so that farmers can gauge anemia in sheep and goats to identify animals that require treatment. For clinically relevant anemia diagnosis, complete blood count-comparable quantitative methods often rely on complicated and expensive optical instruments, requiring detailed spectral information of hemoglobin. We report experimental and numerical results for simple, yet reliable, noninvasive hemoglobin detection that can be correlated with laboratory-based blood hemoglobin testing for anemia diagnosis. In our pilot animal study using calves, we exploit the third eyelid (i.e., palpebral conjunctiva) as an effective sensing site. To further test spectrometer-free (or spectrometerless) hemoglobin assessments, we implement full spectral reconstruction from RGB data and partial least square regression. The unique combination of RGB-based spectral reconstruction and partial least square regression could potentially offer uncomplicated instrumentation and avoid the use of a spectrometer, which is vital for realizing a compact and inexpensive hematology device for quantitative anemia detection in the farm field.
Keyword Spectrometer-free
Anemia
Hemoglobin
Noninvasive detection
Partial least square regression
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: HERDC Pre-Audit
School of Veterinary Science Publications
 
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