Retinal tissue thickness is reduced in diabetic peripheral neuropathy

Srinivasan, Sangeetha, Pritchard, Nicola, Vagenas, Dimitrios, Edwards, Katie, Sampson, Geoff P., Russell, Anthony W., Malik, Rayaz A. and Efron, Nathan (2016) Retinal tissue thickness is reduced in diabetic peripheral neuropathy. Current Eye Research, 41 10: 1359-1366. doi:10.3109/02713683.2015.1119855


Author Srinivasan, Sangeetha
Pritchard, Nicola
Vagenas, Dimitrios
Edwards, Katie
Sampson, Geoff P.
Russell, Anthony W.
Malik, Rayaz A.
Efron, Nathan
Title Retinal tissue thickness is reduced in diabetic peripheral neuropathy
Journal name Current Eye Research   Check publisher's open access policy
ISSN 1460-2202
0271-3683
Publication date 2016-10-01
Sub-type Article (original research)
DOI 10.3109/02713683.2015.1119855
Open Access Status Not yet assessed
Volume 41
Issue 10
Start page 1359
End page 1366
Total pages 8
Place of publication Abingdon, Oxfordshire, United Kingdom
Publisher Taylor & Francis
Language eng
Abstract To investigate the relationship between diabetic peripheral neuropathy (DPN) and retinal tissue thickness.

Full retinal thickness in the central retinal, parafoveal, and perifoveal zones and thickness of the ganglion cell complex and retinal nerve fiber layer (RNFL) were assessed in 193 individuals (84 with type 1 diabetes, 67 with type 2 diabetes, and 42 healthy controls) using spectral domain optical coherence tomography. Among those with diabetes, 44 had neuropathy defined using a modified neuropathy disability score recorded on a 0-10 scale. Multiple regression analysis was performed to investigate the relationship between diabetic neuropathy and retinal tissue thickness, adjusted for the presence of diabetic retinopathy (DR), age, sex, duration of diabetes, and HbA1c levels.

In individuals with diabetes, perifoveal thickness was inversely related to the severity of neuropathy (p < 0.05), when adjusted for age, sex, duration of diabetes, and HbA1c levels. DR was associated with reduced thickness in parafovea (p < 0.01). The RNFL was thinner in individuals with greater degrees of neuropathy (p < 0.04).

DPN is associated with structural compromise involving several retinal layers. This compromise may represent a threat to visual integrity and therefore warrants examination of functional correlates.
Formatted abstract
Aim: To investigate the relationship between diabetic peripheral neuropathy (DPN) and retinal tissue thickness.

Methods: Full retinal thickness in the central retinal, parafoveal, and perifoveal zones and thickness of the ganglion cell complex and retinal nerve fiber layer (RNFL) were assessed in 193 individuals (84 with type 1 diabetes, 67 with type 2 diabetes, and 42 healthy controls) using spectral domain optical coherence tomography. Among those with diabetes, 44 had neuropathy defined using a modified neuropathy disability score recorded on a 0–10 scale. Multiple regression analysis was performed to investigate the relationship between diabetic neuropathy and retinal tissue thickness, adjusted for the presence of diabetic retinopathy (DR), age, sex, duration of diabetes, and HbA1c levels.

Results: In individuals with diabetes, perifoveal thickness was inversely related to the severity of neuropathy (p < 0.05), when adjusted for age, sex, duration of diabetes, and HbA1c levels. DR was associated with reduced thickness in parafovea (p < 0.01). The RNFL was thinner in individuals with greater degrees of neuropathy (p < 0.04).

Conclusions: DPN is associated with structural compromise involving several retinal layers. This compromise may represent a threat to visual integrity and therefore warrants examination of functional correlates.
Keyword Diabetic peripheral neuropathy
Ganglion cell complex
Neuropathy disability score
Retinal nerve fiber layer
Retinal thickness
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
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