Detection of human adaptation during the past 2000 years

Field, Yair, Boyle, Evan A., Telis, Natalie, Gao, Ziyue, Gaulton, Kyle J., Golan, David, Yengo, Loic, Rocheleau, Ghislain, Froguel, Philippe, McCarthy, Mark I. and Pritchard, Jonathan K. (2016) Detection of human adaptation during the past 2000 years. Science, 354 6313: 1-10. doi:10.1126/science.aag0776


Author Field, Yair
Boyle, Evan A.
Telis, Natalie
Gao, Ziyue
Gaulton, Kyle J.
Golan, David
Yengo, Loic
Rocheleau, Ghislain
Froguel, Philippe
McCarthy, Mark I.
Pritchard, Jonathan K.
Title Detection of human adaptation during the past 2000 years
Journal name Science   Check publisher's open access policy
ISSN 1095-9203
0036-8075
Publication date 2016-10-13
Sub-type Article (original research)
DOI 10.1126/science.aag0776
Open Access Status Not yet assessed
Volume 354
Issue 6313
Start page 1
End page 10
Total pages 10
Place of publication Washington, DC, United States
Publisher American Association for the Advancement of Science
Language eng
Subject 1000 General
Abstract Detection of recent natural selection is a challenging problem in population genetics. Here we introduce the Singleton Density Score (SDS), a method to infer very recent changes in allele frequencies from contemporary genome sequences. Applied to data from the UK10K Project, SDS reflects allele frequency changes in the ancestors of modern Britons during the past ~2,000-3,000 years. We see strong signals of selection at lactase and the MHC, and in favor of blond hair and blue eyes. For polygenic adaptation we find that recent selection for increased height has driven allele frequency shifts across most of the genome. Moreover, we identify shifts associated with other complex traits, suggesting that polygenic adaptation has played a pervasive role in shaping genotypic and phenotypic variation in modern humans.
Q-Index Code C1
Q-Index Status Provisional Code
Grant ID 5T32HG000044-19
ES025009
MH101825
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: HERDC Pre-Audit
Institute for Molecular Bioscience - Publications
 
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