Effect of time on recovery of plasma microsamples for the quantitative determination of vancomycin

Parker, Suzanne L., Guerra Valero, Yarmarly C., Lipman, Jeffrey, Roberts, Jason A. and Wallis, Steven C. (2016) Effect of time on recovery of plasma microsamples for the quantitative determination of vancomycin. Bioanalysis, 8 21: 2235-2242. doi:10.4155/bio-2016-0159


Author Parker, Suzanne L.
Guerra Valero, Yarmarly C.
Lipman, Jeffrey
Roberts, Jason A.
Wallis, Steven C.
Title Effect of time on recovery of plasma microsamples for the quantitative determination of vancomycin
Journal name Bioanalysis   Check publisher's open access policy
ISSN 1757-6199
1757-6180
Publication date 2016-11-01
Sub-type Article (original research)
DOI 10.4155/bio-2016-0159
Open Access Status Not yet assessed
Volume 8
Issue 21
Start page 2235
End page 2242
Total pages 8
Place of publication London, United Kingdom
Publisher Future Science
Collection year 2017
Language eng
Abstract The reliability of extraction recovery of an analyte in bioanalysis is fundamentally important for downstream analytical testing. For dried format microsamples, if the recovery changes with time the concentration in clinical samples, derived from calibration standards and alongside quality control samples prepared following different drying protocols, may not reflect the true result. The purpose of this paper was therefore to evaluate changes to extraction recovery across time for one analyte, the glycopeptide antibiotic vancomycin, in plasma using two dried microsampling formats, dried plasma spots and volumetric absorptive microsampling.
Keyword Dried plasma spots (DPS)
Drying time
Microsampling
Quantitation
Recovery
Vancomycin
Volumetric absorptive microsampling (VAMS)
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

 
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