The development of a liquid biopsy for head and neck cancers

Schmidt, Henri, Kulasinghe, Arutha, Kenny, Liz and Punyadeera, Chamindie (2016) The development of a liquid biopsy for head and neck cancers. Oral Oncology, 61 8-11. doi:10.1016/j.oraloncology.2016.07.014

Author Schmidt, Henri
Kulasinghe, Arutha
Kenny, Liz
Punyadeera, Chamindie
Title The development of a liquid biopsy for head and neck cancers
Journal name Oral Oncology   Check publisher's open access policy
ISSN 1368-8375
Publication date 2016-10-01
Sub-type Article (original research)
DOI 10.1016/j.oraloncology.2016.07.014
Open Access Status Not yet assessed
Volume 61
Start page 8
End page 11
Total pages 4
Place of publication Kidlington, Oxford, United Kingdom
Publisher Pergamon Press
Language eng
Subject 3504 Oral Surgery
2730 Oncology
1306 Cancer Research
Abstract Developing non-invasive diagnostic tools in the field of head and neck oncology has been a challenge. Analysis of circulating tumour derivatives in a patient's blood has been explored in other solid cancers. This includes analysis of circulating tumour DNA, intact circulating tumour cells (CTCs) and exosomes. These circulating tumour derivatives provide avenues of investigation which can be representative of a patient's primary tumour signature and can be assessed from a patient's blood sample. In advanced stage cancer patients, these tumour derivatives are found in higher amounts, attributed to higher cellular turnover (apoptosis, autophagy), lysed CTCs and sloughing from necrotic tumours. Head and neck squamous cell carcinoma (HNSCC) patients often present with advanced disease associated with a poor 5-year survival of <50%. Outside of sophisticated imaging and clinical examination, there is a lack of available biomarkers to measure disease burden, and/or response to therapy. Implementation of a liquid biopsy in HNSCC through serial blood samples has the potential to detect metastatic events earlier, thereby allowing better selection of appropriate treatment choices, predict prognosis in patients with potentially curable disease, monitor systemic therapies and residual disease post-treatment.
Keyword Hnscc
Liquid biopsy
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
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