Accuracy of MRI in defining tumor-free margin in optic nerve glioma surgery

Spicer, Galin J., Kazim, Michael, Glass, Lora R. Dagi, Harris, Gerald J., Miller, Neil R., Rootman, Jack and Sullivan, Timothy J. (2013) Accuracy of MRI in defining tumor-free margin in optic nerve glioma surgery. Ophthalmic Plastic and Reconstructive Surgery, 29 4: 277-280. doi:10.1097/IOP.0b013e318291658e


Author Spicer, Galin J.
Kazim, Michael
Glass, Lora R. Dagi
Harris, Gerald J.
Miller, Neil R.
Rootman, Jack
Sullivan, Timothy J.
Title Accuracy of MRI in defining tumor-free margin in optic nerve glioma surgery
Journal name Ophthalmic Plastic and Reconstructive Surgery   Check publisher's open access policy
ISSN 0740-9303
1537-2677
Publication date 2013-07-01
Year available 2013
Sub-type Article (original research)
DOI 10.1097/IOP.0b013e318291658e
Open Access Status Not yet assessed
Volume 29
Issue 4
Start page 277
End page 280
Total pages 4
Place of publication Philadelphia, PA, United States
Publisher Lippincott Williams & Wilkins
Language eng
Abstract Purpose: To determine the value of preoperative MRI in predicting the histopathologic margin of optic nerve glioma undergoing surgical resection.
Formatted abstract
Purpose: To determine the value of preoperative MRI in predicting the histopathologic margin of optic nerve glioma undergoing surgical resection.

Methods: Retrospective, noncomparative, multicenter case series of patients diagnosed with prechiasmal optic nerve glioma, using MRI, who underwent surgical resection. Clinical data were abstracted from patient medical records at 6 medical centers through a survey vehicle. Preoperative MRI findings were compared with intraoperative findings and postoperative histopathologic interpretations of the posterior margins of 13 surgically resected optic nerve gliomas.

Results: A total of 13 patient submissions qualified for study entry based on preoperative MRI having identified a unilateral optic glioma anterior to the optic chiasm. Of these, 2 cases (15%) demonstrated an abnormal macroscopic appearance of the chiasm intraoperatively and were surgically debulked rather than resected as planned preoperatively. The remaining 11 patients underwent resection posterior to the margins indicated by preoperative MRI. Of these, 3 (27%) demonstrated evidence of microscopically positive margins on histopathologic examination. Follow up ranged from 3 months to 21 years. One patient with involvement of the chiasm manifested tumor growth; no other recurrences or evidence of growth occurred inthe remaining patients, including 1 other case with involvement of the chiasm and 3 cases with positive surgical margins.

Conclusions: Unilateral optic nerve gliomas limited to the prechiasmatic nerve on MRI not infrequently extend beyond the MRI borders. This finding is of significance when considering management options, particularly surgical resection.
Keyword Ophthalmology
Surgery
Ophthalmology
Surgery
OPHTHALMOLOGY
SURGERY
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Medicine Publications
 
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