The role of barrier function, autophagy, and cytokines in maintaining intestinal homeostasis

Elshaer, Dana and Begun, Jakob (2016) The role of barrier function, autophagy, and cytokines in maintaining intestinal homeostasis. Seminars in Cell and Developmental Biology, 61 51-59. doi:10.1016/j.semcdb.2016.08.018

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Author Elshaer, Dana
Begun, Jakob
Title The role of barrier function, autophagy, and cytokines in maintaining intestinal homeostasis
Journal name Seminars in Cell and Developmental Biology   Check publisher's open access policy
ISSN 1084-9521
1096-3634
Publication date 2016-08-24
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1016/j.semcdb.2016.08.018
Open Access Status File (Author Post-print)
Volume 61
Start page 51
End page 59
Total pages 9
Place of publication London, United Kingdom
Publisher Academic Press
Collection year 2017
Language eng
Abstract Intestinal homeostasis is maintained through the interplay of the intestinal mucosa, local and systemic immune factors, and the microbial content of the gut. The cellular processes of autophagy, endoplasmic reticulum stress, the unfolded protein response and regulation of reactive oxygen species production are required to maintain a balance between pro-inflammatory responses against potential pathogens and a tolerogenic response towards commensal bacteria. Intestinally active cytokines regulate innate immune pathways and cellular pathways within the gut mucosa. Disruption of these processes, or alterations in the cytokine milieu, can result in an improper response to the commensal gut microbial community leading to inappropriate inflammation characteristic of conditions such as inflammatory bowel disease.
Keyword Mucosal immunity
Autophagy
Intestinal homeostasis
Barrier function
Innate immune pathways
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: Mater Research Institute-UQ (MRI-UQ)
HERDC Pre-Audit
Admin Only - School of Medicine
School of Medicine Publications
 
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Created: Fri, 28 Oct 2016, 21:12:48 EST by Jakob Begun on behalf of Medicine - Mater Hospital