Fundamentals of aerosol therapy in critical care

Dhanani, Jayesh, Fraser, John F., Chan, Hak-Kim, Rello, Jordi, Cohen, Jeremy and Roberts, Jason A. (2016) Fundamentals of aerosol therapy in critical care. Critical Care, 20 1: 269. doi:10.1186/s13054-016-1448-5

Author Dhanani, Jayesh
Fraser, John F.
Chan, Hak-Kim
Rello, Jordi
Cohen, Jeremy
Roberts, Jason A.
Title Fundamentals of aerosol therapy in critical care
Journal name Critical Care   Check publisher's open access policy
ISSN 1466-609X
Publication date 2016-10-07
Year available 2016
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1186/s13054-016-1448-5
Open Access Status DOI
Volume 20
Issue 1
Start page 269
Total pages 16
Place of publication London, United Kingdom
Publisher BioMed Central
Language eng
Abstract Drug dosing in critically ill patients is challenging due to the altered drug pharmacokinetics-pharmacodynamics associated with systemic therapies. For many drug therapies, there is potential to use the respiratory system as an alternative route for drug delivery. Aerosol drug delivery can provide many advantages over conventional therapy. Given that respiratory diseases are the commonest causes of critical illness, use of aerosol therapy to provide high local drug concentrations with minimal systemic side effects makes this route an attractive option. To date, limited evidence has restricted its wider application. The efficacy of aerosol drug therapy depends on drug-related factors (particle size, molecular weight), device factors, patient-related factors (airway anatomy, inhalation patterns) and mechanical ventilation-related factors (humidification, airway). This review identifies the relevant factors which require attention for optimization of aerosol drug delivery that can achieve better drug concentrations at the target sites and potentially improve clinical outcomes.
Keyword Mechanically-Ventilated Patients
Randomized Controlled-Trial
Acute Lung Injury
End-Expiratory Pressure
Seriously Ill Patients
Metered-Dose Inhalers
Q-Index Code C1
Q-Index Status Provisional Code
Grant ID MS2011-40
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: UQ Centre for Clinical Research Publications
HERDC Pre-Audit
Admin Only - School of Medicine
School of Medicine Publications
School of Pharmacy Publications
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 8 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 8 times in Scopus Article | Citations
Google Scholar Search Google Scholar
Created: Tue, 25 Oct 2016, 10:39:44 EST by System User on behalf of Learning and Research Services (UQ Library)