Heritability and genome-wide association analyses of sleep duration in children: the EAGLE consortium

Marinelli, Marcella, Pappa, Irene, Bustamante, Mariona, Bonilla, Carolina, Suarez, Anna, Tiesler, Carla M., Vilor-Tejedor, Natalia, Zafarmand, Mohammad Hadi, Alvarez-Pedrerol, Mar, Andersson, Sture, Bakermans-Kranenburg, Marian J., Estivill, Xavier, Evans, David M., Flexeder, Claudia, Forns, Joan, Gonzalez, Juan R., Guxens, Monica, Huss, Anke, van IJzendoorn, Marinus H., Jaddoe, Vincent W. V., Julvez, Jordi, Lahti, Jari, Lopez-Vicente, Monica, Lopez-Espinosa, Maria-Jose, Manz, Judith, Mileva-Seitz, Viara R., Perola, Markus, Pesonen, Anu-Katriina, Rivadeneira, Fernando, Salo, Perttu P., Shahand, Shayan, Schulz, Holger, Standl, Marie, Thiering, Elisabeth, Timpson, Nicholas J., Torrent, Maties, Uitterlinden, Andre G., Smith, George Davey, Estarlich, Marisa, Heinrich, Joachim, Raikkonen, Katri, Vrijkotte, Tanja G. M., Tiemeier, Henning and Sunyer, Jordi (2016) Heritability and genome-wide association analyses of sleep duration in children: the EAGLE consortium. Sleep, 39 10: 1859-1869. doi:10.5665/sleep.6170


Author Marinelli, Marcella
Pappa, Irene
Bustamante, Mariona
Bonilla, Carolina
Suarez, Anna
Tiesler, Carla M.
Vilor-Tejedor, Natalia
Zafarmand, Mohammad Hadi
Alvarez-Pedrerol, Mar
Andersson, Sture
Bakermans-Kranenburg, Marian J.
Estivill, Xavier
Evans, David M.
Flexeder, Claudia
Forns, Joan
Gonzalez, Juan R.
Guxens, Monica
Huss, Anke
van IJzendoorn, Marinus H.
Jaddoe, Vincent W. V.
Julvez, Jordi
Lahti, Jari
Lopez-Vicente, Monica
Lopez-Espinosa, Maria-Jose
Manz, Judith
Mileva-Seitz, Viara R.
Perola, Markus
Pesonen, Anu-Katriina
Rivadeneira, Fernando
Salo, Perttu P.
Shahand, Shayan
Schulz, Holger
Standl, Marie
Thiering, Elisabeth
Timpson, Nicholas J.
Torrent, Maties
Uitterlinden, Andre G.
Smith, George Davey
Estarlich, Marisa
Heinrich, Joachim
Raikkonen, Katri
Vrijkotte, Tanja G. M.
Tiemeier, Henning
Sunyer, Jordi
Title Heritability and genome-wide association analyses of sleep duration in children: the EAGLE consortium
Journal name Sleep   Check publisher's open access policy
ISSN 0161-8105
1550-9109
Publication date 2016-10-01
Sub-type Article (original research)
DOI 10.5665/sleep.6170
Open Access Status Not yet assessed
Volume 39
Issue 10
Start page 1859
End page 1869
Total pages 11
Place of publication Westchester, IL, United States
Publisher Associated Professional Sleep Societies
Language eng
Abstract Low or excessive sleep duration has been associated with multiple outcomes, but the biology behind these associations remains elusive. Specifically, genetic studies in children are scarce. In this study, we aimed to: (1) estimate the proportion of genetic variance of sleep duration in children attributed to common single nucleotide polymorphisms (SNPs), (2) identify novel SNPs associated with sleep duration in children, and (3) investigate the genetic overlap of sleep duration in children and related metabolic and psychiatric traits.
Formatted abstract
Study Objectives: Low or excessive sleep duration has been associated with multiple outcomes, but the biology behind these associations remains elusive. Specifically, genetic studies in children are scarce. In this study, we aimed to: (1) estimate the proportion of genetic variance of sleep duration in children attributed to common single nucleotide polymorphisms (SNPs), (2) identify novel SNPs associated with sleep duration in children, and (3) investigate the genetic overlap of sleep duration in children and related metabolic and psychiatric traits.

Methods: We performed a population-based molecular genetic study, using data form the EArly Genetics and Life course Epidemiology (EAGLE) Consortium. 10,554 children of European ancestry were included in the discovery, and 1,250 children in the replication phase.

Results: We found evidence of significant but modest SNP heritability of sleep duration in children (SNP h2 0.14, 95% CI [0.05, 0.23]) using the LD score regression method. A novel region at chromosome 11q13.4 (top SNP: rs74506765, P = 2.27e-08) was associated with sleep duration in children, but this was not replicated in independent studies. Nominally significant genetic overlap was only found (rG = 0.23, P = 0.05) between sleep duration in children and type 2 diabetes in adults, supporting the hypothesis of a common pathogenic mechanism.

Conclusions: The significant SNP heritability of sleep duration in children and the suggestive genetic overlap with type 2 diabetes support the search for genetic mechanisms linking sleep duration in children to multiple outcomes in health and disease.
Keyword SNP heritability
Genome-wide association study (GWAS)
Meta-analysis
Childhood sleep duration
Pathway analysis
Q-Index Code C1
Q-Index Status Provisional Code
Grant ID MC_PC_15018
MC_UU_12013/1
MC_UU_12013/3
MC_UU_12013/4
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: HERDC Pre-Audit
UQ Diamantina Institute Publications
 
Versions
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 1 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 0 times in Scopus Article
Google Scholar Search Google Scholar
Created: Sun, 23 Oct 2016, 10:34:37 EST by System User on behalf of Learning and Research Services (UQ Library)