Genetic correlation analysis suggests association between increased self-reported sleep duration in adults and schizophrenia and type 2 diabetes

Byrne, Enda M., Gehrman, Philip R., Trzaskowski, Maciej, Tiemeier, Henning and Pack, Allan I. (2016) Genetic correlation analysis suggests association between increased self-reported sleep duration in adults and schizophrenia and type 2 diabetes. Sleep, 39 10: 1853-1857. doi:10.5665/sleep.6168


Author Byrne, Enda M.
Gehrman, Philip R.
Trzaskowski, Maciej
Tiemeier, Henning
Pack, Allan I.
Title Genetic correlation analysis suggests association between increased self-reported sleep duration in adults and schizophrenia and type 2 diabetes
Journal name Sleep   Check publisher's open access policy
ISSN 0161-8105
1550-9109
Publication date 2016-10-01
Year available 2016
Sub-type Article (original research)
DOI 10.5665/sleep.6168
Open Access Status Not yet assessed
Volume 39
Issue 10
Start page 1853
End page 1857
Total pages 5
Place of publication Westchester, IL United States
Publisher Associated Professional Sleep Societies
Language eng
Formatted abstract
Study Objectives:

We sought to examine how much of the heritability of self-report sleep duration is tagged by common genetic variation in populations of European ancestry and to test if the common variants contributing to sleep duration are also associated with other diseases and traits.

Methods:

We utilized linkage disequilibrium (LD)-score regression to estimate the heritability tagged by common single nucleotide polymorphisms (SNPs) in the CHARGE consortium genome-wide association study (GWAS) of self-report sleep duration. We also used bivariate LD-score regression to investigate the genetic correlation of sleep duration with other publicly available GWAS datasets.

Results:

We show that 6% (SE = 1%) of the variance in self-report sleep duration in the CHARGE study is tagged by common SNPs in European populations. Furthermore, we find evidence of a positive genetic correlation (rG) between sleep duration and type 2 diabetes (rG = 0.26, P = 0.02), and between sleep duration and schizophrenia (rG = 0.19, P = 0.01).

Conclusions:

Our results show that increased sample sizes will identify more common variants for self-report sleep duration; however, the heritability tagged is small when compared to other traits and diseases. These results also suggest that those who carry variants that increase risk to type 2 diabetes and schizophrenia are more likely to report longer sleep duration.
Keyword Genetics
Sleep duration
GWAS
Type 2 diabetes
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: HERDC Pre-Audit
Queensland Brain Institute Publications
 
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