Schistosomiasis vaccines: where do we stand?

Tebeje, Biniam Mathewos, Harvie, Marina, You, Hong, Loukas, Alex and McManus, Donald P. (2016) Schistosomiasis vaccines: where do we stand?. Parasites and Vectors, 9 1: 1-15. doi:10.1186/s13071-016-1799-4

Author Tebeje, Biniam Mathewos
Harvie, Marina
You, Hong
Loukas, Alex
McManus, Donald P.
Title Schistosomiasis vaccines: where do we stand?
Journal name Parasites and Vectors   Check publisher's open access policy
ISSN 1756-3305
Publication date 2016-09-30
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1186/s13071-016-1799-4
Open Access Status DOI
Volume 9
Issue 1
Start page 1
End page 15
Total pages 15
Place of publication London, United Kingdom
Publisher BioMed Central
Language eng
Formatted abstract
Schistosomiasis, caused mainly by S. mansoni, S. haematobium and S. japonicum, continues to be a serious tropical disease and public health problem resulting in an unacceptably high level of morbidity in countries where it is endemic. Praziquantel, the only drug currently available for treatment, is unable to kill developing schistosomes, it does not prevent re-infection and its continued extensive use may result in the future emergence of drug-resistant parasites. This scenario provides impetus for the development and deployment of anti-schistosome vaccines to be used as part of an integrated approach for the prevention, control and eventual elimination of schistosomiasis. This review considers the present status of candidate vaccines for schistosomiasis, and provides some insight on future vaccine discovery and design.
Keyword Antigen discovery
Immune protection
Immune response
Schistosoma haematobium
Schistosoma japonicum
Schistosoma mansoni
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: HERDC Pre-Audit
School of Public Health Publications
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Citation counts: TR Web of Science Citation Count  Cited 15 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 18 times in Scopus Article | Citations
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