Sepsis: frontiers in diagnosis, resuscitation and antibiotic therapy

Perner, Anders, Gordon, Anthony C., de Backer, Daniel, Dimopoulos, George, Russell, James A., Lipman, Jeffrey, Jensen, Jens‑Ulrik, Myburgh, John, Singer, Mervyn, Bellomo, Rinaldo and Walsh, Timothy (2016) Sepsis: frontiers in diagnosis, resuscitation and antibiotic therapy. Intensive Care Medicine, 42 12: 1-12. doi:10.1007/s00134-016-4577-z


Author Perner, Anders
Gordon, Anthony C.
de Backer, Daniel
Dimopoulos, George
Russell, James A.
Lipman, Jeffrey
Jensen, Jens‑Ulrik
Myburgh, John
Singer, Mervyn
Bellomo, Rinaldo
Walsh, Timothy
Title Sepsis: frontiers in diagnosis, resuscitation and antibiotic therapy
Journal name Intensive Care Medicine   Check publisher's open access policy
ISSN 1432-1238
0342-4642
Publication date 2016-10-01
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1007/s00134-016-4577-z
Open Access Status Not yet assessed
Volume 42
Issue 12
Start page 1
End page 12
Total pages 12
Place of publication Heidelberg, Germany
Publisher Springer
Language eng
Abstract Sepsis is a major growing global burden and a major challenge to intensive care clinicians, researchers, guideline committee members and policy makers, because of its high and increasing incidence and great pathophysiological, molecular, genetic and clinical complexity. In spite of recent progress, short-term mortality remains high and there is growing evidence of long-term morbidity and increased long-term mortality in survivors of sepsis both in developed and developing countries. Further improvement in the care of patients with sepsis will impact upon global health. In this narrative review, invited experts describe the expected challenges and progress to be made in the near future. We focus on diagnosis, resuscitation (fluids, vasopressors, inotropes, blood transfusion and hemodynamic targets) and infection (antibiotics and infection biomarkers), as these areas are key, if initial management and subsequent outcomes are to be improved in patients with sepsis.
Keyword Antibiotic
Critical care
Intensive care
Sepsis
Shock
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
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