Evolving insights into RNA modifications and their functional diversity in the brain

Nainar, Sarah, Marshall, Paul R., Tyler, Christina R., Spitale, Robert C. and Bredy, Timothy W. (2016) Evolving insights into RNA modifications and their functional diversity in the brain. Nature Neuroscience, 19 10: 1292-1298. doi:10.1038/nn.4378


Author Nainar, Sarah
Marshall, Paul R.
Tyler, Christina R.
Spitale, Robert C.
Bredy, Timothy W.
Title Evolving insights into RNA modifications and their functional diversity in the brain
Journal name Nature Neuroscience   Check publisher's open access policy
ISSN 1546-1726
1097-6256
Publication date 2016-10-01
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1038/nn.4378
Open Access Status Not yet assessed
Volume 19
Issue 10
Start page 1292
End page 1298
Total pages 7
Place of publication New York, NY, United States
Publisher Nature Publishing Group
Collection year 2017
Language eng
Abstract In this Perspective, we expand the notion of temporal regulation of RNA in the brain and propose that the qualitative nature of RNA and its metabolism, together with RNA abundance, are essential for the molecular mechanisms underlying experience-dependent plasticity. We discuss emerging concepts in the newly burgeoning field of epitranscriptomics, which are predicted to be heavily involved in cognitive function. These include activity-induced RNA modifications, RNA editing, dynamic changes in the secondary structure of RNA, and RNA localization. Each is described with an emphasis on its role in regulating the function of both protein-coding genes, as well as various noncoding regulatory RNAs, and how each might influence learning and memory.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: HERDC Pre-Audit
Queensland Brain Institute Publications
 
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Citation counts: TR Web of Science Citation Count  Cited 4 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 3 times in Scopus Article | Citations
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