Neuronal nicotinic acetylcholine receptor modulators reduce sugar intake

Shariff, Masroor, Quik, Maryka, Holgate, Joan, Morgan, Michael, Patkar, Omkar L., Tam, Vincent, Belmer, Arnauld and Bartlett, Selena E. (2016) Neuronal nicotinic acetylcholine receptor modulators reduce sugar intake. PLoS One, 11 3: . doi:10.1371/journal.pone.0150270

Author Shariff, Masroor
Quik, Maryka
Holgate, Joan
Morgan, Michael
Patkar, Omkar L.
Tam, Vincent
Belmer, Arnauld
Bartlett, Selena E.
Title Neuronal nicotinic acetylcholine receptor modulators reduce sugar intake
Journal name PLoS One   Check publisher's open access policy
ISSN 1932-6203
Publication date 2016-03-30
Year available 2016
Sub-type Article (original research)
DOI 10.1371/journal.pone.0150270
Open Access Status DOI
Volume 11
Issue 3
Total pages 15
Place of publication San Francisco, CA, United States
Publisher Public Library of Science
Language eng
Abstract Excess sugar consumption has been shown to contribute directly to weight gain, thus contributing to the growing worldwide obesity epidemic. Interestingly, increased sugar consumption has been shown to repeatedly elevate dopamine levels in the nucleus accumbens (NAc), in the mesolimbic reward pathway of the brain similar to many drugs of abuse. We report that varenicline, an FDA-approved nicotinic acetylcholine receptor (nAChR) partial agonist that modulates dopamine in the mesolimbic reward pathway of the brain, significantly reduces sucrose consumption, especially in a long-term consumption paradigm. Similar results were observed with other nAChR drugs, namely mecamylamine and cytisine. Furthermore, we show that long-term sucrose consumption increases α4β2 * and decreases α6β2* nAChRs in the nucleus accumbens, a key brain region associated with reward. Taken together, our results suggest that nAChR drugs such as varenicline may represent a novel treatment strategy for reducing sugar consumption
Keyword Multidisciplinary Sciences
Science & Technology - Other Topics
Q-Index Code C1
Q-Index Status Provisional Code
Grant ID FT1110884
Institutional Status Non-UQ
Additional Notes Article number e0150270

Document type: Journal Article
Sub-type: Article (original research)
Collections: HERDC Pre-Audit
Institute for Molecular Bioscience - Publications
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Citation counts: TR Web of Science Citation Count  Cited 7 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 8 times in Scopus Article | Citations
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Created: Thu, 13 Oct 2016, 02:58:42 EST by Mr Michael Morgan on behalf of Learning and Research Services (UQ Library)