Association of mental disorders with subsequent chronic physical conditions: world mental health surveys from 17 countries

Scott, Kate M., Lim, Carmen, Al-Hamzawi, Ali, Alonso, Jordi, Bruffaerts, Ronny, Caldas-de-Almeida, Jose Miguel, Florescu, Silvia, de Girolamo, Giovanni, Hu, Chiyi, de Jonge, Peter, Kawakami, Norito, Elena Medina-Mora, Maria, Moskalewicz, Jacek, Navarro-Mateu, Fernando, O'Neill, Siobhan, Piazza, Marina, Posada-Villa, Jose, Torres, Yolanda and Kessler, Ronald C. (2016) Association of mental disorders with subsequent chronic physical conditions: world mental health surveys from 17 countries. JAMA Psychiatry, 73 2: 150-158. doi:10.1001/jamapsychiatry.2015.2688

Author Scott, Kate M.
Lim, Carmen
Al-Hamzawi, Ali
Alonso, Jordi
Bruffaerts, Ronny
Caldas-de-Almeida, Jose Miguel
Florescu, Silvia
de Girolamo, Giovanni
Hu, Chiyi
de Jonge, Peter
Kawakami, Norito
Elena Medina-Mora, Maria
Moskalewicz, Jacek
Navarro-Mateu, Fernando
O'Neill, Siobhan
Piazza, Marina
Posada-Villa, Jose
Torres, Yolanda
Kessler, Ronald C.
Title Association of mental disorders with subsequent chronic physical conditions: world mental health surveys from 17 countries
Journal name JAMA Psychiatry   Check publisher's open access policy
ISSN 2168-622X
Publication date 2016-02-01
Year available 2016
Sub-type Article (original research)
DOI 10.1001/jamapsychiatry.2015.2688
Open Access Status Not yet assessed
Volume 73
Issue 2
Start page 150
End page 158
Total pages 9
Place of publication Chicago, IL United States
Publisher American Medical Association
Language eng
Formatted abstract
Importance It is clear that mental disorders in treatment settings are associated with a higher incidence of chronic physical conditions, but whether this is true of mental disorders in the community, and how generalized (across a range of physical health outcomes) these associations are, is less clear. This information has important implications for mental health care and the primary prevention of chronic physical disease.

Objective To investigate associations of 16 temporally prior DSM-IV mental disorders with the subsequent onset or diagnosis of 10 chronic physical conditions.

Design, Setting, and Participants Eighteen face-to-face, cross-sectional household surveys of community-dwelling adults were conducted in 17 countries (47 609 individuals; 2 032 942 person-years) from January 1, 2001, to December 31, 2011. The Composite International Diagnostic Interview was used to retrospectively assess the lifetime prevalence and age at onset of DSM-IV–identified mental disorders. Data analysis was performed from January 3, 2012, to September 30, 2015.

Main Outcomes and Measures Lifetime history of physical conditions was ascertained via self-report of physician’s diagnosis and year of onset or diagnosis. Survival analyses estimated the associations of temporally prior first onset of mental disorders with subsequent onset or diagnosis of physical conditions.

Results Most associations between 16 mental disorders and subsequent onset or diagnosis of 10 physical conditions were statistically significant, with odds ratios (ORs) (95% CIs) ranging from 1.2 (1.0-1.5) to 3.6 (2.0-6.6). The associations were attenuated after adjustment for mental disorder comorbidity, but mood, anxiety, substance use, and impulse control disorders remained significantly associated with onset of between 7 and all 10 of the physical conditions (ORs [95% CIs] from 1.2 [1.1-1.3] to 2.0 [1.4-2.8]). An increasing number of mental disorders experienced over the life course was significantly associated with increasing odds of onset or diagnosis of all 10 types of physical conditions, with ORs (95% CIs) for 1 mental disorder ranging from 1.3 (1.1-1.6) to 1.8 (1.4-2.2) and ORs (95% CIs) for 5 or more mental disorders ranging from 1.9 (1.4-2.7) to 4.0 (2.5-6.5). In population-attributable risk estimates, specific mental disorders were associated with 1.5% to 13.3% of physical condition onsets.

Conclusions and Relevance These findings suggest that mental disorders of all kinds are associated with an increased risk of onset of a wide range of chronic physical conditions. Current efforts to improve the physical health of individuals with mental disorders may be too narrowly focused on the small group with the most severe mental disorders. Interventions aimed at the primary prevention of chronic physical diseases should optimally be integrated into treatment of all mental disorders in primary and secondary care from early in the disorder course.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: HERDC Pre-Audit
Queensland Brain Institute Publications
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Citation counts: TR Web of Science Citation Count  Cited 39 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 42 times in Scopus Article | Citations
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Created: Tue, 11 Oct 2016, 23:32:41 EST by Carmen Lim on behalf of Queensland Brain Institute