Of sex and determination: marking 25 years of Randy, the sex-reversed mouse

Koopman, Peter, Sinclair, Andrew and Lovell-Badge, Robin (2016) Of sex and determination: marking 25 years of Randy, the sex-reversed mouse. Development, 143 10: 1633-1637. doi:10.1242/dev.137372

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Author Koopman, Peter
Sinclair, Andrew
Lovell-Badge, Robin
Title Of sex and determination: marking 25 years of Randy, the sex-reversed mouse
Journal name Development   Check publisher's open access policy
ISSN 1477-9129
0950-1991
Publication date 2016-05-15
Sub-type Article (original research)
DOI 10.1242/dev.137372
Open Access Status File (Publisher version)
Volume 143
Issue 10
Start page 1633
End page 1637
Total pages 5
Place of publication Cambridge, United Kingdom
Publisher The Company of Biologists
Collection year 2017
Language eng
Formatted abstract
On Thursday 9 May 1991, the world awoke to front-page news of a breakthrough in biological research. From Washington to Wollongong, newspapers, radio and TV were abuzz with the story of a transgenic mouse in London called Randy. Why was this mouse so special? The mouse in question was a chromosomal female (XX) made male by the presence of a transgene containing the Y chromosome gene Sry. This sex-reversal provided clear experimental proof that Sry was the elusive mammalian sex-determining gene. Twenty-five years on, we reflect on what this discovery meant for our understanding of how males and females arise and what remains to be understood.
Keyword Sex determination
Sry
Testis
Transgenic mouse
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: HERDC Pre-Audit
Institute for Molecular Bioscience - Publications
 
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