Of sex and determination: marking 25 years of Randy, the sex-reversed mouse

Koopman, Peter, Sinclair, Andrew and Lovell-Badge, Robin (2016) Of sex and determination: marking 25 years of Randy, the sex-reversed mouse. Development, 143 10: 1633-1637. doi:10.1242/dev.137372

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Author Koopman, Peter
Sinclair, Andrew
Lovell-Badge, Robin
Title Of sex and determination: marking 25 years of Randy, the sex-reversed mouse
Journal name Development   Check publisher's open access policy
ISSN 1477-9129
Publication date 2016-05-15
Sub-type Article (original research)
DOI 10.1242/dev.137372
Open Access Status File (Publisher version)
Volume 143
Issue 10
Start page 1633
End page 1637
Total pages 5
Place of publication Cambridge, United Kingdom
Publisher The Company of Biologists
Language eng
Formatted abstract
On Thursday 9 May 1991, the world awoke to front-page news of a breakthrough in biological research. From Washington to Wollongong, newspapers, radio and TV were abuzz with the story of a transgenic mouse in London called Randy. Why was this mouse so special? The mouse in question was a chromosomal female (XX) made male by the presence of a transgene containing the Y chromosome gene Sry. This sex-reversal provided clear experimental proof that Sry was the elusive mammalian sex-determining gene. Twenty-five years on, we reflect on what this discovery meant for our understanding of how males and females arise and what remains to be understood.
Keyword Sex determination
Transgenic mouse
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: HERDC Pre-Audit
Institute for Molecular Bioscience - Publications
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Citation counts: TR Web of Science Citation Count  Cited 1 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 1 times in Scopus Article | Citations
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