The role of probiotic bacteria in managing periodontal disease: a systematic review

Matsubara, Victor Haruo, Bandara, H. M. H. N., Ishikawa, Karin Hitomi, Mayer, Marcia Pinto Alves and Samaranayake, Lakshman Perera (2016) The role of probiotic bacteria in managing periodontal disease: a systematic review. Expert Review of Anti-Infective Therapy, 14 7: 643-655. doi:10.1080/14787210.2016.1194198


Author Matsubara, Victor Haruo
Bandara, H. M. H. N.
Ishikawa, Karin Hitomi
Mayer, Marcia Pinto Alves
Samaranayake, Lakshman Perera
Title The role of probiotic bacteria in managing periodontal disease: a systematic review
Journal name Expert Review of Anti-Infective Therapy   Check publisher's open access policy
ISSN 1744-8336
1478-7210
Publication date 2016-07-02
Year available 2016
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1080/14787210.2016.1194198
Open Access Status Not yet assessed
Volume 14
Issue 7
Start page 643
End page 655
Total pages 13
Place of publication Abingdon, Oxfordshire United Kingdom
Publisher Taylor & Francis
Language eng
Abstract The frequent recolonization of treated sites by periodontopathogens and the emergence of antibiotic resistance have led to a call for new therapeutic approaches for managing periodontal diseases. As probiotics are considered a new tool for combating infectious diseases, we systematically reviewed the evidences for their effectiveness in the management of periodontitis.

An electronic search was performed in the MEDLINE, SCOPUS and Cochrane Library databases up to March 2016 using the terms 'periodontitis', 'chronic periodontitis', 'probiotic(s)', 'prebiotic(s)', 'symbiotic(s)', 'Bifidobacterium and 'Lactobacillus'. Only randomized controlled trials (RCTs) were included in the present study. Analysis of 12 RCTs revealed that in general, oral administration of probiotics improved the recognized clinical signs of chronic and aggressive periodontitis such as probing pocket depth, bleeding on probing, and attachment loss, with a concomitant reduction in the levels of major periodontal pathogens. Continuous probiotic administration, laced mainly with Lactobacillus species, was necessary to maintain these benefits. Expert commentary: Oral administration of probiotics is a safe and effective adjunct to conventional mechanical treatment (scaling) in the management of periodontitis, specially the chronic disease entity. Their adjunctive use is likely to improve disease indices and reduce the need for antibiotics.
Formatted abstract
Introduction: The frequent recolonization of treated sites by periodontopathogens and the emergence of antibiotic resistance have led to a call for new therapeutic approaches for managing periodontal diseases. As probiotics are considered a new tool for combating infectious diseases, we systematically reviewed the evidences for their effectiveness in the management of periodontitis.

Areas covered: An electronic search was performed in the MEDLINE, SCOPUS and Cochrane Library databases up to March 2016 using the terms ‘periodontitis’, ‘chronic periodontitis’, ‘probiotic(s)’, ‘prebiotic(s)’, ‘symbiotic(s)’, ‘Bifidobacterium and ‘Lactobacillus’. Only randomized controlled trials (RCTs) were included in the present study. Analysis of 12 RCTs revealed that in general, oral administration of probiotics improved the recognized clinical signs of chronic and aggressive periodontitis such as probing pocket depth, bleeding on probing, and attachment loss, with a concomitant reduction in the levels of major periodontal pathogens. Continuous probiotic administration, laced mainly with Lactobacillus species, was necessary to maintain these benefits.

Expert commentary: Oral administration of probiotics is a safe and effective adjunct to conventional mechanical treatment (scaling) in the management of periodontitis, specially the chronic disease entity. Their adjunctive use is likely to improve disease indices and reduce the need for antibiotics.
Keyword Periodontal diseases
Periodontitis
Probiotics
Lactobacillus
Streptococcus
Inflammation
Dental hygiene
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: HERDC Pre-Audit
School of Dentistry Publications
 
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