The prevalence and burden of bipolar disorder: findings from the Global Burden of Disease Study 2013

Ferrari, Alize J., Stockings, Emily, Khoo, Jon-Paul, Erskine, Holly E., Degenhardt, Louisa, Vos, Theo and Whiteford, Harvey A. (2016) The prevalence and burden of bipolar disorder: findings from the Global Burden of Disease Study 2013. Bipolar Disorders, 18 5: 440-450. doi:10.1111/bdi.12423


Author Ferrari, Alize J.
Stockings, Emily
Khoo, Jon-Paul
Erskine, Holly E.
Degenhardt, Louisa
Vos, Theo
Whiteford, Harvey A.
Title The prevalence and burden of bipolar disorder: findings from the Global Burden of Disease Study 2013
Journal name Bipolar Disorders   Check publisher's open access policy
ISSN 1399-5618
1398-5647
Publication date 2016-08-01
Year available 2016
Sub-type Article (original research)
DOI 10.1111/bdi.12423
Open Access Status Not yet assessed
Volume 18
Issue 5
Start page 440
End page 450
Total pages 11
Place of publication Hoboken, NJ United States
Publisher Wiley-Blackwell Publishing
Language eng
Subject 2738 Psychiatry and Mental health
2803 Biological Psychiatry
Abstract We present the global burden of bipolar disorder based on findings from the Global Burden of Disease Study 2013 (GBD 2013).
Formatted abstract
Objectives
We present the global burden of bipolar disorder based on findings from the Global Burden of Disease Study 2013 (GBD 2013).

Methods
Data on the epidemiology of bipolar disorder were obtained from a systematic literature review and assembled using Bayesian meta-regression modelling to produce prevalence by country, age, sex and year. Years lived with disability (YLDs) were estimated by multiplying prevalence by disability weights quantifying the severity of the health loss associated with bipolar disorder. As there were no years of life lost (YLLs) attributed to bipolar disorder, YLDs equated to disability-adjusted life years (DALYs) as a measure of total burden.

Results
There were 32.7 million cases of bipolar disorder globally in 1990 and 48.8 million in 2013; equivalent to a 49.1% increase in prevalent cases, all accounted for by population increase and ageing. Bipolar disorder accounted for 9.9 million DALYs in 2013, explaining 0.4% of total DALYs and 1.3% of total YLDs. There were 5.5 million DALYs recorded for female individuals and 4.4 million for male individuals. DALYs were evident from age 10 years, peaked in the 20s, and decreased thereafter. DALYs were relatively constant geographically.

Conclusions
Despite being relatively rare, bipolar disorder is a disabling illness due to its early onset, severity and chronicity. Population growth and aging are leading to an increase in the burden of bipolar disorder over time. It is important that resources be directed towards improving the coverage of evidence-based intervention strategies for bipolar disorder and establishing strategies to prevent new cases of the disorder.
Keyword Bipolar disorder
Disability
Epidemiology
Global burden of disease
Prevalence
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: HERDC Pre-Audit
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