Neuroprotective activities of natural products from marine macroalgae during 1999–2015

Alghazwi, Mousa, Kan, Yen Qi, Zhang, Wei, Gai, Wei Ping, Garson, Mary J. and Smid, Scott (2016) Neuroprotective activities of natural products from marine macroalgae during 1999–2015. Journal of Applied Phycology, 28 6: 1-18. doi:10.1007/s10811-016-0908-2

Author Alghazwi, Mousa
Kan, Yen Qi
Zhang, Wei
Gai, Wei Ping
Garson, Mary J.
Smid, Scott
Title Neuroprotective activities of natural products from marine macroalgae during 1999–2015
Journal name Journal of Applied Phycology   Check publisher's open access policy
ISSN 1573-5176
Publication date 2016-08-05
Sub-type Article (original research)
DOI 10.1007/s10811-016-0908-2
Open Access Status Not yet assessed
Volume 28
Issue 6
Start page 1
End page 18
Total pages 18
Place of publication Dordrecht, Netherlands
Publisher Springer Netherlands
Language eng
Subject 1104 Aquatic Science
1110 Plant Science
Abstract This review focuses on macroalgae-derived compounds with neuroprotective activity that may provide lead compounds for the prevention and treatment of neurodegenerative diseases such as Alzheimer’s, Parkinson’s, and Huntington’s disease. Coverage is provided from 1999 to 2015. A total of 99 pure compounds have been reported. The main in vitro bioactivities of these compounds include inhibition of beta amyloid protein (Aβ), inhibition of acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE), reduction in oxidative stress, anti-inflammatory activity, inhibition of kinases, enhancement of neurite outgrowth and the reduction in dopaminergic neurotoxicity. The majority of these bioactive compounds are derived from Phaeophyceae (57.6 %), followed by Rhodophyta (28.3 %) and Chlorophyta (14.1 %). This review presents valuable knowledge on macroalgae-derived compounds and their known pathways of neuroprotection to further explore the potential of these compounds in preventing and treating neurodegenerative diseases.
Keyword Macroalgae
Natural products
Neurodegenerative diseases
Neuroprotective activity
Q-Index Code C1
Q-Index Status Provisional Code
Grant ID 535014
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: HERDC Pre-Audit
School of Chemistry and Molecular Biosciences
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Citation counts: TR Web of Science Citation Count  Cited 5 times in Thomson Reuters Web of Science Article | Citations
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