A hierarchy of timescales explains distinct effects of local inhibition of primary visual cortex and frontal eye fields

Cocchi, Luca, Sale, Martin V., Gollo, Leonardo L., Bell, Peter T., Nguyen, Vinh T., Zalesky, Andrew, Breakspear, Michael and Mattingley, Jason B. (2016) A hierarchy of timescales explains distinct effects of local inhibition of primary visual cortex and frontal eye fields. eLife, 5 Se: . doi:10.7554/eLife.15252


Author Cocchi, Luca
Sale, Martin V.
Gollo, Leonardo L.
Bell, Peter T.
Nguyen, Vinh T.
Zalesky, Andrew
Breakspear, Michael
Mattingley, Jason B.
Title A hierarchy of timescales explains distinct effects of local inhibition of primary visual cortex and frontal eye fields
Journal name eLife   Check publisher's open access policy
ISSN 2050-084X
Publication date 2016-09-06
Sub-type Article (original research)
DOI 10.7554/eLife.15252
Open Access Status DOI
Volume 5
Issue Se
Total pages 17
Place of publication Cambridge, United Kingdom
Publisher eLife Sciences Publications
Language eng
Abstract Within the primate visual system, areas at lower levels of the cortical hierarchy process basic visual features, whereas those at higher levels, such as the frontal eye fields (FEF), are thought to modulate sensory processes via feedback connections. Despite these functional exchanges during perception, there is little shared activity between early and late visual regions at rest. How interactions emerge between regions encompassing distinct levels of the visual hierarchy remains unknown. Here we combined neuroimaging, non-invasive cortical stimulation and computational modelling to characterize changes in functional interactions across widespread neural networks before and after local inhibition of primary visual cortex or FEF. We found that stimulation of early visual cortex selectively increased feedforward interactions with FEF and extrastriate visual areas, whereas identical stimulation of the FEF decreased feedback interactions with early visual areas. Computational modelling suggests that these opposing effects reflect a fast-slow timescale hierarchy from sensory to association areas.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: HERDC Pre-Audit
Queensland Brain Institute Publications
School of Psychology Publications
 
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