Functional genomics and its bench-to-bedside translation pertaining to the identified susceptibility alleles and loci in ankylosing spondylitis

Kenna, Tony J., Hanson, Aimee, Costello, Mary-Ellen and Brown, Matthew A. (2016) Functional genomics and its bench-to-bedside translation pertaining to the identified susceptibility alleles and loci in ankylosing spondylitis. Current Rheumatology Reports, 18 10: . doi:10.1007/s11926-016-0612-x


Author Kenna, Tony J.
Hanson, Aimee
Costello, Mary-Ellen
Brown, Matthew A.
Title Functional genomics and its bench-to-bedside translation pertaining to the identified susceptibility alleles and loci in ankylosing spondylitis
Journal name Current Rheumatology Reports   Check publisher's open access policy
ISSN 1534-6307
1523-3774
Publication date 2016-10-01
Year available 2016
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1007/s11926-016-0612-x
Open Access Status Not yet assessed
Volume 18
Issue 10
Total pages 8
Place of publication Philadelphia, PA, United States
Publisher Springer Healthcare
Collection year 2017
Language eng
Abstract Ankylosing spondylitis (AS) is a highly heritable disease for which there is a great unmet need for improved therapies. Genetics research has identified several major pathways involved in the disease, from which treatments have either now entered clinical practice or are in development. In particular, therapies targeting the IL-23 pathway were repositioned for use in AS following the discovery of multiple genes in the pathway as determinants of AS risk. Discovery of the association of aminopeptidase genes with AS, and subsequently with psoriasis, inflammatory bowel disease and other conditions, has triggered research into therapies targeting this pathway. The AS-genetic associations point to involvement of gut mucosal immunity in driving disease, and metagenomic studies have provided strong support that AS is a disease driven by interaction between the gut microbiome and host immune system, providing a rationale for the exploration of gut-targeted therapies for the disease.
Keyword Aminopeptidase
Ankylosing spondylitis
Functional genomics
Genetics
IL-23
Microbiome
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: HERDC Pre-Audit
UQ Diamantina Institute Publications
 
Versions
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 1 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 1 times in Scopus Article | Citations
Google Scholar Search Google Scholar
Created: Tue, 11 Oct 2016, 10:46:49 EST by System User on behalf of Learning and Research Services (UQ Library)