Growth hormone (GH) enhances anaerobic capacity: impact on physical function and quality of life in adults with GH deficiency

Chikani, Viral, Cuneo, Ross C., Hickman, Ingrid and Ho, Ken K. Y. (2016) Growth hormone (GH) enhances anaerobic capacity: impact on physical function and quality of life in adults with GH deficiency. Clinical Endocrinology, 85 4: 660-668. doi:10.1111/cen.13147


Author Chikani, Viral
Cuneo, Ross C.
Hickman, Ingrid
Ho, Ken K. Y.
Title Growth hormone (GH) enhances anaerobic capacity: impact on physical function and quality of life in adults with GH deficiency
Journal name Clinical Endocrinology   Check publisher's open access policy
ISSN 1365-2265
0300-0664
Publication date 2016-10-01
Year available 2016
Sub-type Article (original research)
DOI 10.1111/cen.13147
Open Access Status Not yet assessed
Volume 85
Issue 4
Start page 660
End page 668
Total pages 9
Place of publication Chichester, West Sussex, United Kingdom
Publisher Wiley-Blackwell Publishing
Language eng
Abstract Context Anaerobic capacity is impaired in adults with GH deficiency (GHD), adversely affecting physical function and quality of life (QoL).
Formatted abstract
Context: Anaerobic capacity is impaired in adults with GH deficiency (GHD), adversely affecting physical function and quality of life (QoL).

Objective: To investigate whether GH replacement improves anaerobic capacity, physical function and QoL in adults with GHD.

Design: One-month double-blind placebo-controlled crossover study of GH (0·5 mg/day), followed by a 6-month open phase.

Patients: A total of 18 adults with GHD.

Measurements: Anaerobic power (watts) was assessed by the 30-s Wingate test, and aerobic capacity by the VO2max (l/min) test. Physical functional was assessed by the stair climb test, chair stand test, 7-day pedometry and QoL by the AGHDA questionnaire. Lean body mass (LBM) was quantified by dual-energy X-ray absorptiometry.

Results: GH replacement normalized IGF-1 levels during both study phases. During the 1-month placebo-controlled study, improvement in stair climb and chair stand performance was observed during GH and placebo treatment; however, there were no significant GH effects observed in any outcome measure compared to placebo. Six months of GH treatment significantly increased anaerobic power (P < 0·05), chair stand repetitions (P < 0·0001), daily step count (P < 0·05) and QoL scores (P < 0·001) compared to baseline measurements. GH treatment did not significantly improve VO2max. Improvement in anaerobic power independently predicted an improvement in energy and vitality domain of QoL (P = 0·03).

Conclusions: GH replacement improves anaerobic capacity, physical function and QoL in a time-dependent manner in adults with GHD. Improvement in the anaerobic but not aerobic energy system is likely to underlie the improvement in QoL in patients with GHD during GH replacement.
Keyword Endocrinology & Metabolism
Endocrinology & Metabolism
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Mater Research Institute-UQ (MRI-UQ)
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