Dosing obese cats based on body weight spuriously affects some measures of glucose tolerance

Reeve-Johnson, M. K., Rand, J. S., Anderson, S. T., Appleton, D. J., Morton, J. M. and Vankan, D. (2016) Dosing obese cats based on body weight spuriously affects some measures of glucose tolerance. Domestic Animal Endocrinology, 57 133-142. doi:10.1016/j.domaniend.2016.05.007

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Author Reeve-Johnson, M. K.
Rand, J. S.
Anderson, S. T.
Appleton, D. J.
Morton, J. M.
Vankan, D.
Title Dosing obese cats based on body weight spuriously affects some measures of glucose tolerance
Journal name Domestic Animal Endocrinology   Check publisher's open access policy
ISSN 0739-7240
1879-0054
Publication date 2016-10-01
Sub-type Article (original research)
DOI 10.1016/j.domaniend.2016.05.007
Open Access Status File (Author Post-print)
Volume 57
Start page 133
End page 142
Total pages 10
Place of publication Philadelphia, PA, United States
Publisher Elsevier
Language eng
Formatted abstract
The primary objective was to investigate whether dosing glucose by body weight results in spurious effects on measures of glucose tolerance in obese cats because volume of distribution does not increase linearly with body weight. Healthy research cats (n = 16; 6 castrated males, 10 spayed females) were used. A retrospective study was performed using glucose concentration data from glucose tolerance and insulin sensitivity tests before and after cats were fed ad libitum for 9 to 12 mo to promote weight gain. The higher dose of glucose (0.5 vs 0.3 g/kg body weight) in the glucose tolerance tests increased 2-min glucose concentrations (P < 0.001), and there was a positive correlation between 2-min and 2-h glucose (r = 0.65, P = 0.006). Two-min (P = 0.016 and 0.019, respectively), and 2-h (P = 0.057 and 0.003, respectively) glucose concentrations, and glucose half-life (T1/2; P = 0.034 and <0.001 respectively) were positively associated with body weight and body condition score. Glucose dose should be decreased by 0.05 g for every kg above ideal body weight. Alternatively, for every unit of body condition score above 5 on a 9-point scale, observed 2-h glucose concentration should be adjusted down by 0.1 mmol/L. Dosing glucose based on body weight spuriously increases glucose concentrations at 2 h in obese cats and could lead to cats being incorrectly classified as having impaired glucose tolerance. This has important implications for clinical studies assessing the effect of interventions on glucose tolerance when lean and obese cats are compared.
Keyword Endocrinology
Glucose tolerance test
Hyperglycaemia
Obesity
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: HERDC Pre-Audit
School of Biomedical Sciences Publications
School of Veterinary Science Publications
 
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