Receptor for advanced glycation end products (RAGE) in type 1 diabetes pathogenesis

Leung, Sherman S., Forbes, Josephine M. and Borg, Danielle J. (2016) Receptor for advanced glycation end products (RAGE) in type 1 diabetes pathogenesis. Current Diabetes Reports, 16 10: 100. doi:10.1007/s11892-016-0782-y


Author Leung, Sherman S.
Forbes, Josephine M.
Borg, Danielle J.
Title Receptor for advanced glycation end products (RAGE) in type 1 diabetes pathogenesis
Journal name Current Diabetes Reports   Check publisher's open access policy
ISSN 1539-0829
1534-4827
Publication date 2016-10-01
Year available 2016
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1007/s11892-016-0782-y
Open Access Status Not yet assessed
Volume 16
Issue 10
Start page 100
Total pages 13
Place of publication Philadelphia, PA, United States
Publisher Springer Healthcare
Language eng
Abstract The receptor for advanced glycation end products (RAGE) is a novel protein increasingly studied in the pathogenesis of type 1 diabetes (T1D). RAGE is expressed by several immune cell types, including T cells, antigen-presenting cells, endothelial cells, and the endocrine cells of the pancreatic islets. RAGE binds various ligands including advanced glycation end products (AGEs), high-mobility group box protein 1 (HMGB1), S100 proteins, β-amyloid, β-sheet fibrils, and lipopolysaccharide. AGEs are a particularly interesting ligand because their exogenous introduction into the body can be accelerated by the consumption of AGE-rich processed foods. This review will detail RAGE isoforms and its ligands and discuss how RAGE binding on the aforementioned cells could be linked to T1D pathogenesis.
Keyword Advanced glycation end products
High-mobility group box protein 1
Immunology
Receptor for advanced glycation end products
S100 calgranulins
Type 1 diabetes pathogenesis
Q-Index Code C1
Q-Index Status Provisional Code
Grant ID Y16G
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: Mater Research Institute-UQ (MRI-UQ)
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Admin Only - School of Medicine
School of Biomedical Sciences Publications
School of Medicine Publications
 
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